Microsoft word - program pages 13th workshop 03-03-06.doc
Scientific Program Thirteenth Workshop on Vitamin D All speaking sessions will be held in the Lecture Theatre of the Victoria Conference Centre. Friday, April 7: PM
Fairmont Empress Hotel, Palm Court/Crystal Ballroom
Saturday, April 8: AM OPENING REMARKS: R. Bouillon, A.W. Norman Session I: VDR and Gene Regulation A – Session Chairpersons: C. Carlberg, M.R. Haussler
Ligand-Induced Transrepression Mechanism by Nuclear
Receptor through Chromatin Remodeling/Modification Complexes
Multiple Enhancer Regions at Significant Distances Upstream
of the Transcriptional Start Site Mediate Rankl Gene Expression in Response to 1,25-Dihydroxyvitamin D3
Structural Basis for the Control of VDR Function in
L.A. Zella
Enhancers Located in the Vitamin D Receptor Gene Mediate
Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D3
Session II: Chemistry and Structure-Function A – Session Chairpersons: A. Mourino, G. Posner
G.H. Posner
Novel Hybrid Analogs of Calcitriol With Unconventional 1-
Substituents and Potentiating Side-Chains
M.T. Mizwicki
On How the Structure-Function Results of 1,25D Side-Chain
Metabolites Can Be Potentially Understood by a VDR Two Pocket Molecular Model
P. DeClercq
Creative Synthesis of Novel Vitamin D Analogs for Health and
Session III: Poster Session A
11:15 – 1:30 PM Saturday, April 8: PM Session IV: Cancer A – Session Chairpersons: D. Feldman, C. Johnson
J.E. Welsh
Vitamin D Signaling in Mammary Gland: What Have We
M.J. Larriba
The Inhibition of WNT/b-Catenin Signaling By 1α,25-
Dihydroxyvitamin D3 Is Abrogated by Snail1 and
Restored by Ectopic VDR Expression in Colon Cancer Cells
H.P. Koeffler
1,25-Dihydroxy Vitamin D3 and its Analogs in Leukemia
Epigenetic Silencing of CYP24 in Tumor-Derived
Endothelial Cells (TDEC) Contributes to Selective Growth Inhibition by Calcitriol
D. Feldman
Calcitriol Regulation of Diverse Target Genes Provides
Multiple Pathways for Inhibition of Prostate Cancer Cell Growth
Session V: Kidney - Actions – Session Chairperson: D. Bikle
H.S. Tenenhouse
Phosphate Transport: Molecular Basis, Regulation and
The Phosphatonins and the Regulation of Phosphate
Session VI: Vitamin D Nutrition Aspects A – Session Chairpersons: R. Mason, R. Bouillon
E. Giovannucci
Predictors of Vitamin D Status and Cancer Incidence
B.A. Gilchrest PLENARY LECTURE: Sun Protection and Vitamin D: Sunday, April 9: AM 8:15 – 8:30 AM Young Investigator Awards Ceremony Session VII: VDR and Gene Regulation B – S. Christakos J.W. Pike
Vitamin D Receptor-Regulated Enhancers Located at
Diverse Sites Within Target Genes Function Both to Modify Chromatin Structure and As Recruitment Centers for RNA Polymerase II
Differential Role of Two VDR Coactivators, DRIP205 and
SRC3, in Keratinocyte Proliferation and Differentiation
C. Carlberg
How Does the Vitamin D Receptor Recognize Its
The Importance of Nuclear Import in Protection of the
Vitamin D Receptor (VDR) from Ubiquitination and Proteasome-Mediated Degradation
Y. Yamamoto
A Tissue-Specific Function by Unliganded Nuclear
Session VIII: Structure-Function B – Session Chairpersons: J.C. Fleet, P. De Clercq
10:20 – 10:40 AM H.F. Deluca
The Use of Selected Analogs of 1α,25-Dihydroxyvitamin D3
R. Masuyama
Partial VDR Rescue in Intestine Reverses Impaired Bone
A. Kittaka
Creative Synthesis of Novel Vitamin D Analogs for Health
Session IX: Poster Session B
11:25 PM – 1:30 PM
Sunday, April 9: PM Session X: Immunology – Session Chairpersons: L. Adorini, C. Mathieu
1:30 – 2:00 PM R. Modlin
TLR2/1 Induction of a Vitamin D Dependent Antimicrobial
Response is Related to Skin Pigmentation
A.R. Martineau
Vitamin D Enhances Antimycobacterial Immunity in vivoC. Mathieu
Novel Insights in the Immune Function of the Vitamin D
Increased NF-kB Activity in Fibroblasts Lacking the Vitamin
Sunday, April 9: PM Session XI: Vitamin D Hydroxylases and Metabolism – Session Chairpersons: H.L. Henry, M. Hewison In Memory of John L. Omdahl and E. Barbara Mawer M. Hewison
Extra-Renal 25-Hydroxyvitamin D3-1α-Hydroxylase in
PTH/cAMP-Induced 1,25-Dihydroxyvitamin D (1,25D)-
C/EBPb Interactions Mediate 1,25D Tight Transcriptional Control of Renal 1,25D Production
Calcium Sensing Receptor-Mediated Regulation of 25-
Hydroxyvitamin D3-1α-Hydroxylase Activity in Human
G.S. Reddy
Metabolism of 1α,25 Dihydroxy-16-ene-20-Epi-Vitamin D3
and its C-3 Epimer through a Novel C-1 Esterification
Pathway in Rat Osteosarcoma Cells (UMR 106)
N. Isoherran
Identification of Human UDP-Glucuronosyltransferases
Catalyzing Hepatic 1α,25-Dihydroxyvitamin D3 Conjugation
J.R. Muindi
CYP24 Splicing Variants Are Associated With Different
Patterns of Constitutive and Calcitriol-Inducible CYP24 Activities in a Human Prostate Cancer Cells
M.J. Rowling
Megalin Mediated Endocytosis of Vitamin D Binding
Protein Correlates with 25-Hydroxyvitamin D3 Actions in
Career Awards Ceremony Monday, April 10: AM Session XII: Transgenic Models –Session Chairperson: M.B. Demay D. Goltzman
New Concepts of Vitamin D Action As Illuminated By
Session XIII: Vitamin D Nutrition Aspects B – Session Chairpersons: S. Whiting, P. Lips
R.P. Heaney PLENARY LECTURE: The Case for Improving Vitamin D S.M. Kimball
Dosing with the Upper Limit for Vitamin D3 Intake Has No
Effect on Serum Calcium or Calcitriol Levels in School Children
The Assessment of Circulating 25(OH)D and 1,25(OH)2D:
Session Chairpersons: A.W. Norman, R. Bouillon
Vitamin D Intake and Nutritional Status in Europe and Asia
S.J. Whiting
Dietary Intakes of Vitamin D in North America and In Asia-
Pacific Countries Are Not Sufficient to Prevent Vitamin D Insufficiency
Review of Vitamin D Safety: Revision of the Tolerable
B.W. Hollis
Circulating Vitamin D3 and 25(OH)D in Humans: An
Important Tool to Define Adequate Nutritional Vitamin D Status
Summary of the North American Conference on UV,
OPEN FORUM
FREE AFTERNOON Tuesday, April 11: AM Session XIV: Renal Osteodystrophy – Session Chairperson: E. Slatopolsky, R. Thadhani In Memory of Jack W. Coburn A.J. Brown
Secondary Hyperparathyroidism and Vitamin D Analogs:
M.V. Arcidiacono
TGFa/EGFE-Induction of Dominant Negative C/EBPB
(LIP) Mediates the Severity of Parathyroid Hyperplasia and the Onset of Vitamin D Resistance in Chronic Kidney Disease
R. Thadhani
Therapeutic Role of Vitamin D Receptor Activator in
Session XV: Rapid Responses – Session Chairperson: B. Boyan, A.W. Norman B.D. Boyan
1α,25(OH)2D3 Is an Autocrine Regulator of ECM
Turnover and Growth Factor Release Via ERP60 Activated Matrix Vesicle MMPS
A.W. Norman
1α,25(OH)2D3, Nucleus, Genomic Responses,
Caveolae, Rapid Responses, Vitamin D Receptor WT and KO: Integration via a Conformational Ensemble Model
K.M. Dixon In Vivo Relevance for Photoprotection by the Vitamin D
Session XVI: Hair – Session Chairperson: R. Kumar
10:55 – 11:15 AM M.B. Demay
Role of the Vitamin D Receptor in Hair Follicle Biology
Session XVII: Poster Session C
11:20 – 1:30 PM Tuesday, April 11: PM Session XVIII: Cancer B – Session Chairpersons: D.L. Trump, G. Studzinski
L. Adorini
Control of Prostate Growth and Inflammation by the Vitamin
M.J. Campbell
Identifying 1α,25(OH)2D3-Responsive Transcriptional
M.F. Holick
Evaluation of Novel Gemini Vitamin D Analogs for the
Treatment of Colon, Prostate and Pancreatic Cancers
T.M. Beer
Targeting the Vitamin D Receptor with High Dose Pulse
C. Johnson
Calcitriol Enhances Anti-Tumor Activity of
Ketoconazole/Dexamethasone in vitro and in vivo in Human Prostate Cancer PC-3 Model Through Caspase-8/Caspase 6 and Mitochondrial/AIF Apoptotic Pathways
P.P. Dwivedi
Role of Oncoprotein Growth Factor Independent-1 (GFI1) in
Repression of 25-Hydroxyvitamin D 1-alpha Hydroxylase (CYP27B1) Gene In Human Prostate Cancer Cells
Session XIX: Bone – Session Chairpersons: J.P.T.M. van Leeuwen, H.F. Deluca
N. Kurihara
Enhanced Vitamin D Receptor-Mediated Signal
Transduction Appears to Be Requested for Development of Pagetic Osteoclasts
P.H. Anderson
Autocrine Activities of 1α,25(OH)2D3 in Human Osteoblast-
P.T.M. van
TRPV Calcium Channels, Vitamin D and Bone Metabolism
Session XX: Skin-Heart - Session Chairperson: M. Garabedian
Sequential Regulation of Keratinocyte Differentiation By
R. Simpson
Characterization of Heart Function and Structure in the
7:00 – 10:00 PM Grand Banquet at the Royal BC Museum
Wednesday, April 12: AM
Session XXI: Osteoporosis – Session Chairpersons: J.C. Gallagher, N. Kubodera
T. Matsumoto
ED-71, A New Active Vitamin D, Increases Bone Mass
Regardless of Serum 25(OH)D Levels in Osteoporotic Subjects
H. Bischoff-
Estimation of Optimal Serum 25-Hydroxyvitamin D Levels
J.C. Gallagher
An Age Related Decrease in Creatine Clearance is
Associated with an Increase in Number of Falls in Untreated Women but Not Women Receiving Calcitriol
COFFEE BREAK Session XXII: VDR and Gene Regulation B – Session Chairpersons: J.H. White, J.W. Pike M.R. Haussler
1,25-Dihydroxyvitamin D3 (1,25D) and Fibroblast Growth
Factor-23 (FGF-23), Inextricably Linked Reciprocal Endocrine Partners in the Regulation of Phosphate and Bone Metabolism
J.H. White
Genomic Approaches to Identification of 1,25-
Dihydroxyvitamin D3 Target Genes Implicated in its
L. Verlinden
1α,25-Dihydroxyvitamin D3-Induced Down-Regulation of the
Checkpoint Proteins, CHEK1 and CLASPIN, is Mediated by the Pocket Proteins p107 and P130
S. Christakos
New Insights into the Function and Regulation of Vitamin D
H.D. Marks
Transgenic Expression of the Human Vitamin D Receptor
(VDR) in Duodenum of VDR-Null Mice Attenuates Age-Dependent Decline in Calcium Absorption
P. Dhawan
Novel Regulation by Glucocorticoids of 25-Hydroxyvitamin
D3 24-Hydroxylase (24(OH)ASE) Through A Functional
Renal Protective Role of Vitamin D in the Development of
CLOSING REMARKS: R. Bouillon, A.W. Norman
B.S. in Health Systems Management Proposed Program Assessment Plan February 21, 2007 Teaching Mission Statement of the School of Public Affairs (draft statement) The School of Public Affairs provides students with a high quality education which emphasizes the acquisition of skills and knowledge in their chosen profession. Our programs emphasize mastery of knowledge in their field of st
J o u r n a l o f Oral RehabilitationArthrocentesis with or without additional drugsin temporomandibular joint inflammatory-degenerativedisease: comparison of six treatment protocols*D . M A N F R E D I N I , D . R A N C I T E L L I , G . F E R R O N A T O & L . G U A R D A - N A R D I N I TMDClinic, Department of Maxillofacial Surgery, University of Padova, Padova, ItalySUMMARY The aim o