Tosca lucie flore
Laboratory address : UMR CNRS 8080 "Développement et Evolution"
Université Paris-Sud IBAIC, Bât 444 91405 Orsay Cedex, FRANCE [email protected]
Education and research experiment:
2007-2009 Post-Doctoral position
- National Center of Scientific Research (CNRS), Laboratory
of Developmental biology and Evolution, University Paris Sud, Orsay, France. Supervisor : B. Ciapa.
→ Role of the PLCγ et MEK/ERK pathways in the initiation of fertilization and mitotic
calcium signals, apoptosis control and early development in the sea urchin.
2004-2007 Ph.D. (Reproductive biology)
- University François Rabelais, Tours, France. Practical
training at the National Institute of Agronomical Research (INRA) of Nouzilly, France. Laboratory of Reproductive Physiology and Behavior. Supervisor : J. Dupont. → Role of 5’AMP-activated protein kinase (AMPK) in reproduction : characterization in ovary and pituitary.
2003-2004 Master’s Degree (Endocrinology and Cellular Interactions)
- University of Medicine
Paris Sud, Kremlin Bicêtre, France. Practical training at the Atomic Energy Center (CEA), Fontenay-aux-Roses, France. Laboratory of Gametogenesis, Apoptosis and Genotoxicity. Supervisors : B. Lefèvre and C. Finaz.
→ Involvement of caspase-3 in meiotic and/or apoptosis during mouse oocyte in vitro
International practical training
: McGill Unversity, Royal Victoria Hospital of
Montreal, Canada. Laboratory of Reproductive Biology. Supervisor : R.C. Chian.
→ In vitro
maturation, in vitro
fertilization and in vitro
embryo culture in bovine species.
Main publications: Tosca L
, Chabrolle C, Dupont J. AMPK, Métabolisme et fertilité femelle. Med Sci 2008, 24(3):297-
Arnault E, Tosca L
, Courtot AM, Doussau M, Pesty A, Finaz C, Allemand I, Lefèvre B. Presence of
caspase-2, caspase-3, and caspase-9 in the mature mouse oocyte: their roles during meiosis and/or
apoptosis in vitro. Dev Dyn 2008 (in revision).
Coyral-Castel S, Tosca L
, Ferreira G, Jeanpierre E, Ramé C, Lomet D, Caraty A, Monget P, Chabrolle
C, Dupont J. The effect of AMPK activation on GnRH secretion in GT1-7 cells and its potential role in
hypothalamic regulation of the œstrus cyclicity in rats. J Neuroendocrinol 2008, 20(3):335-46. Tosca L
, Chabrolle C, Crochet S, Tesseraud S, Dupont J. IGF-1 receptor signaling pathways and
effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells. Domest
Anim Endocrinol 2008, 34(2):204-16.
Chung JT, Tosca L
, Huang TH, Xu L, Niwa K, Chian RC. Effect of polyvinylpyrrolidone on bovine
oocyte maturation in vitro
and subsequent fertilization and embryonic development. Reprod Biomed
Online 2007, 15(2):198-207.
, Uzbekova S, Chabrolle C, Dupont J. Possible role of 5’AMP-activated protein kinase in the
metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro
Biol Reprod 2007, 77(3):452-65.
Chabrolle C, Tosca L
, Dupont J. Regulation of adiponectin and its receptors in rat ovary by human
chorionic gonadotrophin treatment and potential involvement of adiponectin in granuloca cell
steroidogenesis. Reproduction 2007, 133(4):719-31.
Chabrolle C, Uzbekova S, Dupont J. Effects of metformin on bovine granulosa cells
steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase
(AMPK). Biol Reprod 2007, 76(3):368-78.
Expression of adiponectin and its receptors
(AdipoR1 and AdipoR2) in chicken ovary: Potential role in ovarian steroidogenesis. Domest Anim
Endocrinol 2007, 33(4):480-7. Tosca L
activation modulates progesterone secretion in granulosa cells from hen preovulatory follicles. J
Endocrinol 2006, 190(1):85-97.
in-induced stimulation of adenosine 5'
monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells.
Biol Reprod 2006, 75(3):342-51.
, Adenosine 5'-monophosphate-activated
protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology 2005,
Last Name First Name DOB County Mother's Name Vol Cert # ACTON Lela G 18 Jun 1903 Whitley Fannie Hubbs 184 47424 ADAMS Chester 06 Nov 1908 Whitley Amanda Jenkins 160 46447 ADAMS Mabel I 04 Dec 1910 Whitley Mollie Goodin 202 48152 ADKINS Hattie 20 Mar 1903 Whitley Eliza Higginboth 170 46872 ADKINS Myrtle M 25 Sep 1898 Whitley Dona Goins 226 49098 ADKINS Sidney O 31 Jul 1898 Whitley Rachel Smith 16
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