Microsoft word - commission-sanctioned thresholds - approved 1-24-13 docx _2_.doc

Approved by Commission, 3/23/06, 5/18/06, 1/25/07, 2/21/08, 6/19/08, 5/21/09, 6/18/09, 3/25/10, 6/16/11, 8/11/11, 1/26/12, 3/20/12, 1/24/13 DIRECTIVE ON
COMMISSION-SANCTIONED THRESHOLDS
[3A:205.2(H)]
THERAPEUTIC MEDICATIONS
(1)
A finding by the Primary Laboratory of a prohibited drug, chemical or other substance in a test specimen of a horse is prima facie evidence that the prohibited drug, chemical or other substance was administered to the horse and, in the case of a post-race test, was present in the horse's body while it was participating in a race. Prohibited substances include: Drugs or medications for which no acceptable threshold concentration has been established; Therapeutic medications in excess of Commission-Sanctioned Threshold concentrations as set forth below; Environmental contaminants and substances of human use present in the horse in excess of Commission-Sanctioned Thresholds as set forth below; Any medication, drug, substance, or metabolic derivative thereof that might mask or screen the presence of prohibited drugs, or prevent or delay testing procedures. The use of the following therapeutic medications shall be permitted not less than twenty-four (24) hours before post time for the race in which the horse is entered, provided the concentration in the horse's plasma/serum sample or specimen does not exceed the following levels when tested post race: Flunixin: 100 ng/ml plasma/serum effective 6/2/08 Directive on Commission-Sanctioned Thresholds Oklahoma Horse Racing Commission Approved 3/23/06, 5/18/06, 1/25/07, 2/21/08, 6/19/08, 5/21/09, 6/18/09, 3/25/10, 6/16/11, 8/11/11, 1/26/12, 3/20/12, 1/24/13 Methylprednisolone: 2 ng/ml plasma/serum. Triamcinolone Acetonide: 1 ng/ml plasma/serum. • The threshold level for Quarter Horses, Paints and • The threshold level for Thoroughbreds is 0.275 ng/ml • Beginning August 1, 2013, the threshold level for Thoroughbreds will become 0.025 ng/ml [25 pg/ml]. Procaine Penicillin: 25 ng/ml serum/plasma.
*Plasma/Serum Level - Negative/LOD: Less than the limit of detection of the
method.
Directive on Commission-Sanctioned Thresholds Oklahoma Horse Racing Commission Approved 3/23/06, 5/18/06, 1/25/07, 2/21/08, 6/19/08, 5/21/09, 6/18/09, 3/25/10, 6/16/11, 8/11/11, 1/26/12, 3/20/12, 1/24/13

The use of these therapeutic medications and Phenylbutazone is subject to the
following additional conditions:
the presence of more than two permitted non-steroidal anti-inflammatory drugs in the post-race serum is prohibited; and the presence of more than two permitted corticosteroids in the post-race serum is prohibited. Although the following environmental contaminants and/or substances may be found in the horse, no sample or specimen shall exceed the following levels when tested post race: Cocaine: 150 ng/ml urine (Benzoyl Ecgonine Metabolite). Anabolic Steroids [approved by Commission, 6/18/09] The presence of anabolic steroids in a race horse is strictly prohibited except for the presence of the following approved anabolic steroids at plasma/serum levels below Commission-Sanctioned Thresholds: These levels are based upon a 60 day withdrawal and became effective
on 8/18/09, the 61st day after approval by the Commission on 6/18/09.
Directive on Commission-Sanctioned Thresholds Oklahoma Horse Racing Commission Approved 3/23/06, 5/18/06, 1/25/07, 2/21/08, 6/19/08, 5/21/09, 6/18/09, 3/25/10, 6/16/11, 8/11/11, 1/26/12, 3/20/12, 1/24/13 Salix [Furosemide] and Bute [Phenylbutazone], a Non-Steroidal Anti- The following two rules in OHRC Rules of Racing reflect the acceptable level of Furosemide [Salix] and Phenylbutazone [Bute], respectively: Rule 325:45-1-9, Furosemide (Salix) Use Without Detention Barn (2) The Commission has established a post race plasma concentration level not to exceed 100 ng/ml of Furosemide (Salix]. (2) The permitted quantitative test level of Phenylbutazone shall not exceed 5 micrograms (ug) per milliliter (ml) of plasma. Other acceptable therapeutic medications. In light of the fact that scientific research is an evolving process in recognizing therapeutic medications at non-performance enhancing levels, the Commission acknowledges that the laboratory may detect levels for therapeutic medications not previously identified in this Directive. In the event of detection of a medication that is subsequently established as routine and safe to use in the industry, it should be considered as a mitigating factor in any disciplinary action taken against the affected Trainer. (7) Owner’s and Trainer’s Assumption of the Risk. In an effort to allow horses that have been treated with specified therapeutic medications to race, the Commission has replaced its no tolerance standard for those medications with Commission-Sanctioned Thresholds. As specified above, under this Directive, a specified therapeutic medication may be used if two (2) conditions are met: The medication must be administered at least 24 hours prior to post time of the race in which the horse is entered, and The post-race concentration level of the medication in the horse’s plasma/serum Directive on Commission-Sanctioned Thresholds Oklahoma Horse Racing Commission Approved 3/23/06, 5/18/06, 1/25/07, 2/21/08, 6/19/08, 5/21/09, 6/18/09, 3/25/10, 6/16/11, 8/11/11, 1/26/12, 3/20/12, 1/24/13 While the Commission established thresholds are based on scientific studies, there is no guarantee that administration of an allowed therapeutic
medication twenty-four (24) hours prior to post time will result in a concentration
level of the medication that complies with Commission-Sanctioned Thresholds,
as the condition of the horse, the horse’s metabolism, the route of drug
administration, the dosage of the drug administered, and other factors may affect
the post-race levels of the medication in the horse’s plasma or serum.
Accordingly, owners and trainers who use a permitted therapeutic
medication assume the risk that, even if the drug is administered twenty-
four (24) hours prior to post time, the concentration level of the medication
in the horse’s plasma or serum may, nevertheless, exceed the
Commission-Sanctioned Threshold for the medication.
Owners and trainers should also understand that the use of Commission- Sanctioned Thresholds, rather than the use of a no tolerance standard, is the only margin of error allowed. There is no margin of error allowed above the Commission-Sanctioned Thresholds. Approved by Oklahoma Horse Racing Commission, 3/23/06; 5/18/06, 1/25/07, 2/21/08, 6/19/08, 5/21/09, 6/18/09, 3/25/10, 6/16/11, 8/11/11, 1/26/12, 3/20/12, 1/24/13

Source: http://www.ohrc.org/Commission-Sanctioned%20Thresholds%20-%20approved%201-24-13%20docx%20_2_.pdf