La spécificité du tadalafil est liée à sa longue demi-vie, permettant une action qui excède largement celle des autres inhibiteurs de PDE5. L’absorption digestive est complète, avec un pic plasmatique atteint en 2 heures environ. Le métabolisme est réalisé via CYP3A4, produisant des métabolites inactifs éliminés principalement dans les fèces. La sélectivité enzymatique est élevée, réduisant les effets indésirables extra-caverneux. Les réactions indésirables fréquentes incluent céphalées, bouffées vasomotrices et troubles digestifs légers. L’activité pharmacologique est stable, indépendamment de l’ingestion d’aliments. Dans les comparaisons de longue durée, acheter cialis pas cher est mentionné en relation avec les études portant sur la persistance d’efficacité et la constance de la cinétique plasmatique.

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MOLECULAR FUNCTION & IMAGING SYMPOSIUM: SATURDAY MAY 23RD 2009

7:00-7:30
Registration & Breakfast
Grand Scheme Foyer & Delivered Ballroom 7:15-7:30
Welcoming Remarks
Dr Rob Beanlands
ICRH / MFI TRANSLATIONAL WORKSHOPS I
7:30-8:30
Session A
Dr Erik Suuronen
Stem Cell and Regenerative Therapies: How to
Make the Leap from Lab Bench to Clinical
Dr Duncan Stewart*
Application and Evaluation
Mr Joe Irvine / Dr Nadine Tatton
7:30-8:30
Session B
Dr Rob deKemp
Cardiac Molecular Imaging: How Can Imaging
Approaches Enhance Basic & Clinical
Dr Matthias Friedrich
Research?
Dr Joseph Wu*
ICRH / MFI TRANSLATIONAL WORKSHOPS II

8:30-9:30
Session C
Dr Glenn Wells
Vascular Molecular Imaging: How Can
Imaging Approaches Enhance Basic & Clinical
Dr Jean-Claude Tardif*
Research?
Dr Alan Moody
08:30-9:30
Session D
Dr Ting Lee
Molecular Imaging for the Non-Imaging
Scientist: Options & Opportunities
Dr Matthias Friedrich
Dr Peter Burns
University of Toronto
Dr Frank Bengel*
Johns Hopkins University
MOLECULAR FUNCTION & IMAGING SYMPOSIUM: 9:30-9:45
COFFEE BREAK & POSTER SET-UP
Grand Scheme Foyer & Pavilion SESSION I – BASIC SCIENCE OF CARDIAC REGENERATIVE THERAPY
KEYNOTE LECTURE I
9:45-10:30
Cell Based Therapies for Cardiovascular Diseases: Dr Duncan Stewart
ORAL ABSTRACT SESSION I (10:30 − 12:00)
Patrick Burgon (UOHI) Miran Kenk (PhD Candidate, UOHI) 10:30-10:45
A Tissue-Engineered Biomatrix Enhances the Dr Pingchuan Zhang
Therapeutic Effects of Circulating Progenitor Cells Division of Cardiac Surgery University of Ottawa Heart Institute 10:45-11:00
An Injectable Collagen-Chitosan Hydrogel: Dr Chao Deng
Preparation, Physical Properties and Angiogenic Division of Cardiac Surgery University of Ottawa Heart Institute 11:00-11:15
Collagen Capsule as a Drug-delivery Vehicle Zahra Arzhangi
MSc Student
University of Ottawa Eye Institute
11:15-11:30
Controlled Release of Stromal Cell Derived Drew Kuraitis
Factor-1 to Enhance Progenitor Cell Recruitment PhD Candidate Division of Cardiac Surgery University of Ottawa Heart Institute 11:30-11:45
Bone Marrow Cells Attenuate Renal and Cardiac Dr Darren Yuen
Injury in a Model of Progressive Chronic Kidney St Michael’s Hospital University of Toronto 11:45-12:00
Bone Marrow Clara Cell Secretory Protein- Dr Martha Bustos
Expressing Cells Rescue Mice with Irreversible Latner Thoracic Surgery Laboratories University of Toronto MOLECULAR FUNCTION & IMAGING SYMPOSIUM: 12:00-12:45
LUNCH AND POSTER SESSION
SESSION II – PRECLINICAL IMAGING
KEYNOTE LECTURE II

12:45-13:30
Tracking of Stem Cell Therapy in Cardiac Disease Dr Joseph Wu
ORAL ABSTRACT SESSION II (13:30 – 15:00)

Moderator:
Dr Pasan Fernando (MDS Nordion, UOHI) Ran Klein (PhD Candidate, UOHI) 13:30-13:45
Labeling Circulating Progenitor Cells Using the Dr Tayebeh Hadizad
Lipophilic Ligand Hexadecyl-4-[18F]fluoro- PET Radiochemistry Laboratory University of Ottawa Heart Institute 13:45-14:00
Development of Non-Invasive PET Imaging for Mary Zhang
the Long-Term Assessment of Progenitor Cells Division of Cardiac Surgery University of Ottawa Heart Institute 14:00-14:15
Ultrasound-Mediated Gene Delivery of Growth Alexandra Smith
Factors Promotes Sustained New Blood Vessel St Michael’s Hospital University of Toronto 14:15-14:30
[11C]Methyl-Candesartan Displays Binding Sheryn Kirkpatrick
Specificity for Angiotensin II AT1 Receptors PET BioTesting Laboratory University of Ottawa Heart Institute 14:30-14:45
Application of New Bifunctional Chelates for Adam Smith
Excellence (MICE) MDS Nordion University of Ottawa Heart Institute 14:45-15:00
PDE4 Specific Binding is Observed in Rat Heart Adam Thomas
using (R)-[11C]Rolipram and Small Animal PET MSc Candidate PET BioTesting Laboratory University of Ottawa Heart Institute 15:00-15:15
COFFEE BREAK
MOLECULAR FUNCTION & IMAGING SYMPOSIUM: SESSION III – CLINICAL IMAGING
KEYNOTE LECTURE III

15:15-16:00
Translation of Stem Cell Imaging to Human Dr Frank Bengel
ORAL ABSTRACT SESSION III (16:00-17:30)

Moderator:
Dr Glenn Wells (UOHI) Dr Abdulaziz Alghamdi (Clinical Fellow, UOHI) 16:00-16:15
Amir Pourmoghaddas
Characteristics using Respiratory Motion Imaging Physics University of Ottawa Heart Institute 16:15-16:30
Test-retest Repeatability of Myocardial SPECT Dr Iftikhar Ali
Cardiac Imaging University of Ottawa Heart Institute 16:30-16:45
Metabolic Characterization of the Human R225W Sean Crawford
AMPKγ3 Mutation Reveals Increased Oxidative Capacity, Leak Dependent Respiration, and 16:45-17:00
Characterization of Patients with Preserved and Dr Maria Cecilia Ziadi
Reduced Myocardial Flow Reserve Measured Cardiac Imaging University of Ottawa Heart Institute 17:00-17:15
Reduced Cardiac Function with Cardiac Edema Myra Cocker
and Hyperemia in Elite High-Endurance Athletes with Common Colds: A Cardiovascular Magnetic Libin Cardiovascular Institute of Alberta 17:15-17:30
Characterization of the Cardiotoxic Effects of Brooke Hogarth
Chemotherapies by Contrast-Enhanced Cardiac Libin Cardiovascular Institute of Alberta CLOSE OF SESSIONS
17:30-17:40
Dr Robert Roberts
President, CEO, Chief Science Officer
University of Ottawa Heart Institute

Source: http://www.lightbox.ca/~mfi/sup_files/MFI2009_program.pdf