Feline Herpesvirus-1 as This recurrence may present as a striking eosinophilic dermatitis
of the face and/or nasal planum (occasionally on the extremities)
a differential diagnosis that is easily mistaken by both clinicians and histopathologists
for allergic eosinophilic dermatitis or eosinophilic granuloma complex. While the literature indicates pruritus may be moderate
for feline facial pruritus to absent (Gross et al.
, 2005), some cases have marked
pruritus and resulting self-mutilation which compounds the clinical confusion with allergic pruritus. This commonly results
C&T No. 5245
in a fruitless diagnostic work-up for allergic disease as well as ineffectual and possibly aggravating immunosuppressive
Long Green Animal Dermatology Center, P.C.
Histopathology of biopsy specimens reveals a necrotizing
eosinophilic dermatitis. Intranuclear viral inclusions may not
be present or may be easily missed by the histopathologist.
Both PCR and immunohistochemical techniques have been
investigated and validated as screening tools for herpetic dermatitis (Hargis et al., 1999, Persico et al.
, 2011). However, the discovery of the safe and effective use of the human antiviral, Famciclovir, has revolutionized our ability to both diagnose and treat this disease (Thomasy et al.
, 2006, Malik et al., 2009, Thomasy et al.
, 2011). The author recommends a 2 to 3 week empirical course of Famciclovir as a diagnostic rule out in cases of feline facial dermatitis and pruritus where herpes may be suspected (125 mg PO BID). In the author’s experience, response is noted in many cases of nebulous feline facial excoriation and dermatitis that were previously misdiagnosed as allergic in etiology and treated unsuccessfully with steroids and/or cyclosporine. The veterinary practitioner should be mindful of this insidious differential diagnosis when confronted with refractory feline facial dermatitis cases.
Figure 1. Feline herpetic facial dermatitis
Gross TL et al.
, Feline herpesvirus ulcerative dermatitis. In: Skin Diseases of
the Dog and Cat. Clinical and Histopathologic Diagnosis
, 2nd edition. Oxford: Blackwell Science, 124-126, 2005.
Hargis A.M. et al
. Ulcerative facial and nasal dermatitis and stomatitis in cats
associated with feline herpesvirus-1. Veterinary Dermatology.
10: 267-74, 1999.
Malik R et al.
Treatment of feline herpesvirus-1 associated disease in cats with
famciclovir and related drugs. J Feline Med Surg
. 11(1): 40-48, 2009.
Persico P et al.
Detection of feline herpes virus 1 via polymerase chain reaction
and immunohistochemistry in cats with ulcerative facial dermatitis, eosinophilic granuloma complex reaction patterns and mosquito bite hypersensitivity. Veterinary Dermatology.
22: 521-527, 2011.
Thomasy SM et al.
, Safety and efficacy of famciclovir in cats infected with feline
herpesvirus 1. Veterinary Ophthalmology.
Thomasy SM et al.
Evaluation of orally administered famciclovir in cats
experimentally infected with feline herpesvirus type-1. Am J Vet Res.
72(1): 85-95, 2011.
Figure 2. The patient post treatment
Feline patients with allergic disease can present clinically with a reaction pattern known as head and neck pruritus. This
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severe and most frustrating of feline reaction patterns can
complementary e-book format as well as print.
result in dramatic mutilation and is often refractory to numerous treatments. A typical list of differential diagnoses includes:
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disease (Flea allergy, food allergy and atopy). Often overlooked is the possibility of feline herpesvirus ulcerative dermatitis.
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Feline Herpesvirus-1 (FHV-1) is most commonly associated with
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keratoconjunctivitis. Following primary infection, it is harbored in
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the trigeminal ganglion in latency. Following immunosuppression
format AND the 4 prior issues (Sept 2011, Dec 2011,
or stress, viral replication can reactivate and result in recurrence.
10 Control & Therapy Series – 268
Authors’ views are not necessarily those of the CVE
Listado de Expedientes de Aprobación de Planos con Notificaciones de Requerimientos para Prosecución de Tramites Nº de Expediente Año Recurrente Cta. Cte. Ctral. Nº 2008 AIDA HERRERA DE HUTTEMAN (INTRV. MUNIC 276) 2006 ALBERTO ACOSTA (FINANCIERA FAMILIAR) 2008 ALBERTO GUNTHER-AGROP.MAIZ CUE S.A. 2009 ANA MARIA DELGADILLO CARDOZO Y OTRO 2008 ANTONIA MA. LOURDES VERA DE
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