High rates of muscle glycogen resynthesis after exhaustive ex.
High rates of muscle glycogen resynthesis after exhaustive exercise w.
J Appl Physiol 105: 7-13, 2008. First published May 8, 2008; doi:10.1152/japplphysiol.01121.2007 8750-7587/08 $8.00 This Article High rates of muscle glycogen resynthesis after exhaustive exercise Full Text Full Text (PDF) when carbohydrate is coingested with caffeine All Versions of this Article: 105/1/7 most recent 01121.2007v1 David J. Pedersen, Sarah J. Lessard, Vernon G. Coffey, Emmanuel G. Churchley, Andrew M. Wootton, Submit a response They Ng, Matthew J. Watt, and John A. Hawley Alert me when this article is cited Alert me when eLetters are posted School of Medical Sciences, RMIT University, Bundoora, Victoria, AustraliaAlert me if a correction is posted Citation Map
Submitted 18 October 2007 ; accepted in final form 30 April 2008
We determined the effect of coingestion of caffeine (Caff) with carbohydrate (CHO) on rates of muscle
Email this article to a friend
glycogen resynthesis during recovery from exhaustive exercise in seven trained subjects who completed two
Similar articles in this journal Similar articles in PubMed
experimental trials in a randomized, double-blind crossover design. The evening before an experiment subjects
Alert me to new issues of the journal
performed intermittent exhaustive cycling and then consumed a low-CHO meal. The next morning subjects
Download to citation manager
rode until volitional fatigue. On completion of this ride subjects consumed either CHO [4 g/kg body mass
(BM)] or the same amount of CHO + Caff (8 mg/kg BM) during 4 h of passive recovery. Muscle biopsies and
Articles by Pedersen, D. J.
blood samples were taken at regular intervals throughout recovery. Muscle glycogen levels were similar at
Articles by Hawley, J. A.
exhaustion [ 75 mmol/kg dry wt (dw)] and increased by a similar amount ( 80%) after 1 h of recovery (133 ±
37.8 vs. 149 ± 48 mmol/kg dw for CHO and Caff, respectively). After 4 h of recovery Caff resulted in higher
glycogen accumulation (313 ± 69 vs. 234 ± 50 mmol/kg dw, P < 0.001). Accordingly, the overall rate of
Articles by Pedersen, D. J. Articles by Hawley, J. A.
resynthesis for the 4-h recovery period was 66% higher in Caff compared with CHO (57.7 ± 18.5 vs. 38.0 ±
7.7 mmol·kg dw–1·h–1, P < 0.05). After 1 h of recovery plasma Caff levels had increased to 31 ± 11 µM (P <
0.001) and at the end of the recovery reached 77 ± 11 µM (P < 0.001) with Caff. Phosphorylation of CaMKThr286 was similar after exercise and after
1 h of recovery, but after 4 h CaMKThr286 phosphorylation was higher in Caff than CHO (P < 0.05). Phosphorylation of AMP-activated protein
kinase (AMPK)Thr172 and AktSer473 was similar for both treatments at all time points. We provide the first evidence that in trained subjects
coingestion of large amounts of Caff (8 mg/kg BM) with CHO has an additive effect on rates of postexercise muscle glycogen accumulation compared
Akt; AMP-activated protein kinase; Ca2+/calmodulin-dependent kinase
Address for reprint requests and other correspondence: J. A. Hawley, School of Medical Sciences, RMIT Univ., PO Box 71, Bundoora 3083, Victoria,Australia (e-mail: [email protected])
Códigos de Educación 2012-2013 Página 1 CÓDIGO DE EDUCACIÓN DEL ESTADO DE CALIFORNIA, SECCIÓN 48900 : Un alumno(a) no deberá ser suspendido(a) de la escuela o recomendado(a) para expulsión, a menos que el superintendente o el director de la escuela a la que asiste el alumno(a) determine que el estudiante ha cometido un acto como se define de acuerdo a una o más de las subdivisi
Le point sur les véritables propriétés de la potion qui « donne des ailes» Lorella CIUTTO, Delphine LAMALLE, Mélanie PROD’HOM Mots-clés : Redbull, boisson énergisante, caféine, taurine, glucuronolactone Introduction Selon les ethnies, les générations, les religions ou encore les croyances personnelles, de nombreuses et différentes vertus sont attribuées à certains alime