La spécificité du tadalafil est liée à sa longue demi-vie, permettant une action qui excède largement celle des autres inhibiteurs de PDE5. L’absorption digestive est complète, avec un pic plasmatique atteint en 2 heures environ. Le métabolisme est réalisé via CYP3A4, produisant des métabolites inactifs éliminés principalement dans les fèces. La sélectivité enzymatique est élevée, réduisant les effets indésirables extra-caverneux. Les réactions indésirables fréquentes incluent céphalées, bouffées vasomotrices et troubles digestifs légers. L’activité pharmacologique est stable, indépendamment de l’ingestion d’aliments. Dans les comparaisons de longue durée, acheter cialis pas cher est mentionné en relation avec les études portant sur la persistance d’efficacité et la constance de la cinétique plasmatique.
Elenco Pubblicazioni in extenso di Enrico Aitini e Colleghi
Struttura Complessa di Oncologia Medica ed Ematologia
(autore, co-autore, principal investigator, main co-investigator) Franciosi V, Barbieri R, Aitini E et al: GEMCITABINE AND OXALIPLATIN: A SAFE AND ACTIVE REGIMEN IN POOR PROGNOSIS ADVANCED NON-SMALL CELL LUNG CANCER PATIENTS. Lung Cancer. 2003 Jul;41(1):101-6 Gridelli C, Gallo C… Pari F,Aitini E et al: GEMCITABINE PLUS VINORELBINE COMPARED WITH CISPLATIN PLUS VINORELBINE OR CISPLATIN PLUS GEMCITABINE FOR ADVANCED NON-SMALL-CELL LUNG CANCER: A PHASE III TRIAL OF THE ITALIAN GEMVIN INVESTIGATORS AND THE NATIONAL CANCER INSTITUTE OF CANADA CLINICAL TRIALS GROUP. J Clin Oncol. 2003 Aug Di Maio M, Perrone F…Pari F,Aitini E et al: SUPPORTIVE CARE IN PATIENTS WITH ADVANCED NON-SMALL-CELL LUNG CANCER. Br J Cancer. 2003 Sep 15;89(6):1013-21 The ATAC Trialist s’Group (among principal investigators: Aitini E, Cavazzini G) ANASTROZOLE ALONE OR IN COMBINATION WITH TAMOXIFEN VERSUS TAMOXIFEN ALONE FOR ADJUVANT TREATMENT OF POSTMENOPAUSAL WOMEN WITH EARLY-STAGE BREAST CANCER: RESULTS OF THE ATAC (ARIMIDEX, TAMOXIFEN ALONE OR IN COMBINATION) TRIAL EFFICACY AND SAFETY UPDATE ANALYSES. Cancer. 2003 Nov CantoreM, Fiorentini G…Zamagni D, Aitini E et al: RANDOMISED TRIAL OF GEMCITABINE VERSUS FLEC REGIMEN GIVEN INTRA-ARTERIALLY FOR PATIENTS WITH UNRESECTABLE PANCREATIC CANCER. J Exp Clin Cancer Res. 2003 Dec
Guida M, Ravaioli A…Pari F, Aitini E .et al:
FIBRINOGEN: A NOVEL PREDICTOR OF RESPONSIVENESS IN METASTATIC MELANOMA PATIENTS TREATED WITH BIO-CHEMOTHERAPY: IMI (ITALIAN MELANOMA INTER-GROUP) TRIAL. J Transl Med. 2003 Dec CantoreM, Fiorentini G…Zamagni, Rabbi C et al. MOLECULAR THERAPY: CLINICAL APPLICATIONS. INTRA-ARTERIAL ADENOVIRUSES ADMINISTRATION. J Exp Clin Cancer Res. 2003 Venturini M,Aitini E, Cavazzini G et al: DOSE-DENSE ADJUVANT CHEMOTHERAPY IN EARLY BREAST CANCER PATIENTS: FIRST RESULTS FROM A RANDOMIZED TRIAL. Breast Cancer Res Treat, 2003 CantoreM, Fiorentini G…Zamagni D, Rabbi C et al. COMBINED IRINOTECAN AND OXALIPLATIN IN PATIENTS WITH ADVANCED PRE-TREATED PANCREATIC CANCER. Oncology. 2004 Intergroup Exemestane Study (among principal investigators: Aitini E) A RANDOMIZED TRIAL OF EXEMESTANE AFTER TWO TO THREE YEARS OF TAMOXIFEN THERAPY IN POSTMENOPAUSAL WOMEN WITH PRIMARY BREAST CANCER. N Engl J Med. 2004 Mar Labianca R, Fossati R, Zaniboni A (among principal investigators: Aitini E, Rabbi C) RANDOMIZED TRIAL OF INTRAPORTAL AND/OR SYSTEMIC ADJUVANT CHEMOTHERAPY IN PATIENTS WITH COLON CARCINOMA. J Natl Cancer Inst. 2004 May
ON THE BANKS OF THE LIFE: I TUMORI GIOVANILI NELLA POESIA E NELLA LETTERATURA Tumori, May 2004 suppl. CantoreM, Rabbi C, Zamagni D, et al. GEMCITABINE VERSUS FLEC REGIMEN GIVEN INTRA-ARTERIALLY TO PATIENTS WITH UNRESECTABLE PANCREATIC CANCER: A PROSPECTIVE, RANDOMIZED PHASE III TRIAL OF THE ITALIAN SOCIETY FOR INTEGRATED LOCOREGIONAL THERAPY IN ONCOLOGY. J Chemother. 2004 Dec The ATAC Trialist s’Group (among principal investigators: Aitini E, Cavazzini G) RESULTS OF THE ATAC (ARIMIDEX, TAMOXIFEN, ALONE OR IN COMBINATION) TRIAL AFTER COMPLETION OF 5 YEARS' ADJUVANT TREATMENT FOR BREAST CANCER. Lancet. 2005 Jan Mambrini A,…Zamagni, Rabbi C et al. INTRA-ARTERIAL HEPATIC CHEMOTHERAPY IN HEAVILY PRETREATED PATIENTS WITH EPITHELIAL OVARIAN CANCER. Ann Oncol. 2005 Feb Louvet C, Labianca R… Aitini E et al:
GEMCITABINE IN COMBINATION WITH OXALIPLATIN COMPARED WITH GEMCITABINE ALONE IN LOCALLY ADVANCED OR METASTATIC PANCREATIC CANCER: RESULTS OF A GERCOR AND GISCAD PHASE III TRIAL. J Clin Oncol. 2005 May 20;23(15):3509-16. Ardizzoni A, Favaretto A…Pari F et al: PLATINUM-ETOPOSIDE CHEMOTHERAPY IN ELDERLY PATIENTS WITH SMALL-CELL LUNG CANCER: RESULTS OF A RANDOMIZED MULTICENTER PHASE II STUDY ASSESSING ATTENUATED-DOSE OR FULL-DOSE WITH LENOGRASTIM PROPHYLAXIS--A FORZA OPERATIVA NAZIONALE ITALIANA CARCINOMA POLMONARE AND GRUPPO STUDIO TUMORI POLMONARI VENETO (FONICAP-GSTPV) STUDY. J Clin Oncol. 2005 Jan
Piccart M et al (among principal investigators: Cavazzini G)
TRANSTUZUMAB AFTER ADJUVANT CHEMOTHERAPY IN HER2-POSITIVE BREAST CANCER. The New England Journal of Medicine 333; 1659-1672. 2005
CantoreM, Mambrini A,…Zamagni, Rabbi C et al.
PHASE II STUDY OF HEPATIC INTRAARTERIAL EPIRUBICIN AND CISPLATIN, WITH SYSTEMIC 5-FLUOROURACIL IN PATIENTS WITH UNRESECTABLE BILIARY TRACT TUMORS. Cancer. 2005 Apr Del Mastro L, Nicolò…. Cavazzini G, Aitini E et al: HER2 EXPRESSION AND EFFICACY OF DOSE-DENSE ANTHRACYCLINE-CONTAINING ADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS. Br J Cancer. 2005 Jul 11;93(1):7-14.
Twelves C et al (among principal investigators: Rabbi C)
CAPECITABINE AS ADJUVANT TREATMENT FOR STAGE III COLON CANCER. N Engl J Med. 2005 Jun Venturini M, Del Mastro L, Aitini E, Cavazzini G et al: DOSE-DENSE ADJUVANT CHEMOTHERAPY IN EARLY BREAST CANCER PATIENTS: RESULTS FROM A RANDOMIZED TRIAL. J Natl Cancer Inst. 2005 Dec 7;97(23):1724-33. Aitini E, Aleotti P: BREAKING BAD NEWS IN ONCOLOGY: LIKE A WALK IN THE TWILIGHT?
Aitini E, Cetto GL: A GOOD DEATH FOR CANCER PATIENTS: STILL A DREAM? Annals of Oncology, May 2006 The ATAC Trialist s’Group (among principal investigators: Aitini E, Cavazzini G) IMPACT OF CHEMOTHERAPY REGIMENS PRIOR TO ENDOCRINE THERAPY: RESULTS FROM THE ATAC (ANASTROZOLE AND TAMOXIFEN, ALONE OR IN COMBINATION) TRIAL. Cancer. 2006 Aug Di Bartolomeo M, Buzzoni R…Aitini E et al: FEASIBILITY OF SEQUENTIAL THERAPY WITH FOLFIRI FOLLOWED BY DOCETAXEL/CISPLATIN IN PATIENTS WITH RADICALLY RESECTED GASTRIC ADENOCARCINOMA. A RANDOMIZED PHASE III TRIAL. Oncology. 2006 The ATAC Trialist s’Group (among principal investigators: Aitini E, Cavazzini G) COMPREHENSIVE SIDE-EFFECT PROFILE OF ANASTROZOLE AND TAMOXIFEN AS ADJUVANT TREATMENT FOR EARLY-STAGE BREAST CANCER: LONG-TERM SAFETY ANALYSIS OF THE ATAC TRIAL. Lancet Oncology 2006; 7:633-43 Aitini E, Sempreboni A, Aleotti P, Zamagni D, Cavazzini G, Barbieri R, Cengarle R, Pari F, Rabbi C and Vivorio B: ANXIETY LEVELS IN CANCER PATIENTS AND "LIFE SOUND" EXPERIENCE. Tumori. 2007 Jan Bajetta E, Di Bartolomeo M…Aitini E .et al: URACIL/FTORAFUR/LEUCOVORIN COMBINED WITH IRINOTECAN (TEGAFIRI) OR OXALIPLATIN (TEGAFOX) AS FIRST-LINE TREATMENT FOR METASTATIC COLORECTAL CANCER PATIENTS: RESULTS OF RANDOMISED PHASE II STUDY. Br J Cancer. Feb 2007 Droghetti A, Schiavini A, …Aitini E .et al:
CHEST WALL RECONSTRUCTION IN FULL-THICKNESS DEFECT FOR
MASTECTOMY AND IRRADIATION. Ann Thorac Surg. Feb 2007
Bidoli P, Zilembo L…Aitini E, Pari F .et al:RANDOMIZED PHASE II THREE-ARM TRIAL WITH THREE PLATINUM-BASED DOUBLETS IN METASTATIC NON-SMALL-CELL LUNG CANCER. AN ITALIAN TRIALS IN MEDICAL ONCOLOGY STUDY. Ann Oncol. Mar 2007 Intergroup Exemestane Study (among principal investigators: Aitini E)
SKELETAL EFFECTS OF EXEMESTANE ON BONE-MINERAL DENSITY, BONE BIOMARKERS, AND FRACTURE INCIDENCE IN POSTMENOPAUSAL WOMEN WITH EARLY BREAST CANCER PARTICIPATING IN THE INTERGROUP EXEMESTANE STUDY (IES): A RANDOMISED CONTROLLED STUDY. Lancet Oncol. 2007 Feb Intergroup Exemestane Study (among principal investigators: Aitini E)
SURVIVAL AND SAFETY OF EXEMESTANE VERSUS TAMOXIFEN AFTER 2-3 YEARS' TAMOXIFEN TREATMENT (INTERGROUP EXEMESTANE STUDY): A RANDOMISED CONTROLLED TRIAL.
Lancet. 2007 Feb Cascinu S, Labianca R… Aitini E, Rabbi C .et al:ADJUVANT TREATMENT OF HIGH-RISK, RADICALLY RESECTED GASTRIC CANCER PATIENTS WITH 5-FLUOROURACIL, LEUCOVORIN, CISPLATIN, AND EPIDOXORUBICIN IN A RANDOMIZED CONTROLLED TRIAL. J Natl Cancer Inst. 2007 Apr Del Mastro L, Dozin B, Aitini E…Cavazzini G et al:TIMING OF ADJUVANT CHEMOTHERAPY AND TAMOXIFEN IN WOMEN WITH BREAST CANCER: FINDINGS FROM TWO CONSECUTIVE TRIALS OF GRUPPO ONCOLOGICO NORD-OVEST MAMMELLA INTERGRUPPO (GONO MIG) GROUP. Ann Oncol. 2007 Oct Aitini E and Cavazzini G: DESIGN AND ARCHITECTURE IN ONCOLOGY AS SUPPORTIVE CARE FOR CANCER PATIENTS Tumori, Nov 2007 Pagani M, Antico A, Bellarosa S, Cavazzini G and Aitini E: PRIMARY PULMONARY HIGH GRADE NON-HODGKIN’S LYMPHOMA IN AN ELDERLY PATIENT. A CASE REPORT Tumori, Nov 2007
Galli L, Fontana A… Aitini E, Barbieri R et al: PHASE II STUDY OF SEQUENTIAL CHEMOTHERAPY WITH DOCETAXEL-ESTRAMUSTINE FOLLOWED BY MITOXANTRONE-PREDNISONE IN PATIENTS WITH ADVANCED HORMONE-REFRACTORY PROSTATE CANCER. Br J Cancer. 2007 Nov Cascinu S, Berardi R … Aitini E, .et al:CETUXIMAB PLUS GEMCITABINE AND CISPLATIN COMPARED WITH GEMCITABINE AND CISPLATIN ALONE IN PATIENTS WITH ADVANCED PANCREATIC CANCER: A RANDOMISED, MULTICENTRE, PHASE II TRIAL. Lancet Oncol. 2007 Dec
(Formerly multiple personality disorder) A fact sheet produced by the Mental Health Information Service What is Dissociation? Dissociation is a mental process where there is a lack of connection between memories, thoughts, feelings, actions or sense of identity. This disconnection is termed ‘splitting’ and exists at a sub-conscious level. The process of dissociation exists on a continuum.
The Method – New and old Technology Assessment methods Serious game How far would you go to become stronger, fitter or more competitive? Ritalin for your child to improve its educational chances? A robotic arm to boost strength? With the Rathenau Instituut’s new human enhancement app you can put your ethics to the test. spend time in training or use enhancements – mild and rad