La spécificité du tadalafil est liée à sa longue demi-vie, permettant une action qui excède largement celle des autres inhibiteurs de PDE5. L’absorption digestive est complète, avec un pic plasmatique atteint en 2 heures environ. Le métabolisme est réalisé via CYP3A4, produisant des métabolites inactifs éliminés principalement dans les fèces. La sélectivité enzymatique est élevée, réduisant les effets indésirables extra-caverneux. Les réactions indésirables fréquentes incluent céphalées, bouffées vasomotrices et troubles digestifs légers. L’activité pharmacologique est stable, indépendamment de l’ingestion d’aliments. Dans les comparaisons de longue durée, acheter cialis pas cher est mentionné en relation avec les études portant sur la persistance d’efficacité et la constance de la cinétique plasmatique.
Microsoft word - easa npa 2008 17b 3 jun 2008 human factors.doc
NPA 200817b 3 Jun 2008 (Compiled: Juergen Knueppel, for INFO from Orig.200608) Page 287 of 647 Aeroplane, Helicopter PPL
040 00 00 00 HUMAN PERFORMANCE 040 01 00 00 HUMAN FACTORS: BASIC CONCEPTS 040 01 01 00 Human Factors in aviation 040 01 01 02 Becoming a competent pilot 040 02 00 00 BASIC AVIATION PHYSIOLOGY AND HEALTH MAINTENANCE 040 02 01 01 The atmosphere – composition – gas Laws 040 02 01 02 Respiratory and circulatory systems – oxygen requirement of tissues – functional anatomy – main forms of hypoxia (hypoxic and anaemic) – sources, effects and countermeasures of carbon monoxide – counter measures, hypoxia – symptoms of hypoxia – hyperventilation – the effects of accelerations on the circulatory system hypertension and coronary heart isease 040 02 02 00 Man and Environment 040 02 02 01 Central, peripheral and autonomic nervous systems 040 02 02 02 Vision – functional anatomy – visual field, foveal and peripheral vision – binocular and monocular vision – monocular vision cues – night vision – visual scanning and detection techniques and importance of “lookout” defective vision 040 02 02 03 Hearing – descriptive and functional anatomy – flight related hazards to hearing hearing loss 040 02 02 04 Equilibrium – functional anatomy – motion and acceleration – motion sickness 040 02 02 05 Integration of sensory inputs – spatial disorientation: forms, recognition, avoidance – illusions: forms, recognition, avoidance, physical origin – physiological origin – psychological origin – approach and landing problems 040 02 03 00 Health and hygiene 040 02 03 01 Personal hygiene personal fitness 040 02 03 02 Body rhythm and sleep rhythm disturbances symptoms, effects, management 040 02 03 03 Problem areas for pilots common minor ailments including cold, influenza and gastrointestinal upset, entrapped gases, baro-trauma (scuba diving),obesity, food hygiene, infectious diseases, nutrition, various toxic gases and materials
040 02 03 04 Intoxication – tobacco – alcohol – caffeine – drugs and selfmedication 040 03 00 00 BASIC AVIATION PSYCHOLOGY 040 03 01 00 Human information processing 040 03 01 01 Attention and vigilance – selectivity of attention – divided attention 03 01 02 Perception – perceptual illusions – subjectivity of perception – processes of perception 040 03 01 03 Memory – sensory memory – working/short term memory – long term memory to include motor memory (skills) 040 03 02 00 Human error and reliability 040 03 02 01 Reliability of human behaviour 040 03 02 04 Error generation – social environment (group, organisation) 040 03 03 00 Decision making 040 03 03 01 Decisionmaking concepts – structure (phases) – limits – risk assessment practical application 040 03 04 00 Avoiding and managing errors: cockpit management 040 03 04 01 Safety awareness – risk area awareness – situational awareness 040 03 04 04 Communication – verbal and nonverbal communication 040 03 05 00 Human behaviour 040 03 05 01 Personality and attitudes – development – environmental influences 040 03 05 03 Identification of hazardous attitudes (error proneness) 040 03 06 00 Human overload and underload 040 03 06 01 Arousal 040 03 06 02 Stress – definition(s) – anxiety and stress – effects of stress 040 03 06 05 Fatigue and stress management types, causes and symptoms of fatigue effects of fatigue – coping strategies – management techniques – health and fitness programmes NPA 200817b Page 289 of 647
Directeur de la publication : Edwy Plenel Jean Charpentier, neurochirurgien, qui a travaillé dansl’équipe de recherche du laboratoire et a réalisé desétudes sur le Mediator à partir de 1969. Charpentier, en tant qu’expert pharmacologue-ARTICLE PUBLIÉ LE SAMEDI 25 JANVIER 2014toxicologue agréé par le ministère de la santéParmi les quinze personnes physiques mises enpubliq
1 Chapter 0: Preliminaries 1.1 Contents of This Chapter • Analysis Versus Numerical Analysis • Describes how numerical analysis differs from analytical analysis and shows where each has special • It briefly lists the topics that will be covered in later chapters • Explains why computers and numerical analysis are intimately related • It describes several ways by which a comput