Microsoft word - mini_cv_lahoutte

Tony Lahoutte
Profil professionnel
 Charge de cours (Docent) 10% ZAP, VUB - 1/10/2006  Charge de cours 5%, UMH – 1/10/2009 – 30-9-2014  Chef de Clinique en Médecine Nucléaire, UZ Brussel - 1/10/  Maître de Recherches Cliniques du Fonds de la Recherche Scientifique Flandre, 1/10/2007  Chef de recherche du labo « in vivo cellular and molecular imaging» à la VUB, 1/10/2006 Formation
 1999 : Laboratory Animal Science, UGent  2000 : Master in Medical and Pharmaceutical Research, VUB  2004 : Thèse de doctorat en Sciences Médicales, VUB  2005 : Médecin Specialist en Médecine Nucléaire Publications scientifiques
 V. Caveliers, H. Everaert, T. Lahoutte, L. O. Dierickx, C. S. John, and A. Bossuyt, Labelled
sigma receptor ligands: can their role in neurology and oncology be extended?, in Eur J Nucl
Med, vol. 28, pp. 133-5, Feb 2001.
 L. O. Dierickx, T. Lahoutte, P. Deron, V. Caveliers, C. Vanhove, H. Everaert, and A.
Bossuyt, Diagnosis of recurrent head and neck squamous cell carcinoma with 3-[123I]iodo-L-
alpha-methyltyrosine SPET,in Eur J Nucl Med, vol. 28, pp. 282-7, Mar 2001.
 T. Lahoutte, V. Caveliers, L. Dierickx, M. Vekeman, H. Everaert, J. Mertens, and A.
Bossuyt, "In vitro characterization of the influx of 3-[125I]iodo-L-alpha-methyltyrosine and 2-
[125I]iodo-L-tyrosine into U266 human myeloma cells: evidence for system T transport," in Nucl
Med Biol, vol. 28, pp. 129-34, Feb 2001.
 V. Caveliers, H. Everaert, C. S. John, T. Lahoutte, and A. Bossuyt, "Sigma receptor
scintigraphy with N-[2-(1'-piperidinyl)ethyl]-3-(123)I-iodo-4-methoxybenzamide of patients with
suspected primary breast cancer: first clinical results," in J Nucl Med, vol. 43, pp. 1647-9, Dec
2002.
 T. Lahoutte, V. Caveliers, P. R. Franken, A. Bossuyt, J. Mertens, and H. Everaert, "Increased
tumor uptake of 3-(123)I-Iodo-L-alpha-methyltyrosine after preloading with amino acids: an in
vivo animal imaging study," in J Nucl Med, vol. 43, pp. 1201-6, Sep 2002.
 L. O. Dierickx, H. Everaert, P. Deron, M. Voordeckers, T. Lahoutte, and A. Bossuyt,
"Evaluation of the response to therapy of head and neck squamous cell carcinoma by using 3- [123I]iodo-L-alpha-methyl tyrosine and single photon emission tomography," in Nucl Med
Commun, vol. 24, pp. 633-41, Jun 2003.
 H. Everaert, H. De Boeck, K. Muylle, T. Lahoutte, and A. Bossuyt, "Hypertrophic osteitis of
the clavicle," in Clin Nucl Med, vol. 28, pp. 990-1, Dec 2003.
 H. Everaert, C. Vanhove, T. Lahoutte, K. Muylle, V. Caveliers, A. Bossuyt, and P. R.
Franken, "Optimal dose of 18F-FDG required for whole-body PET using an LSO PET camera,"
in Eur J Nucl Med Mol Imaging, vol. 30, pp. 1615-9, Dec 2003.
 T. Lahoutte, J. Mertens, V. Caveliers, P. R. Franken, H. Everaert, and A. Bossuyt,
"Comparative biodistribution of iodinated amino acids in rats: selection of the optimal analog for
oncologic imaging outside the brain," in J Nucl Med, vol. 44, pp. 1489-94, Sep 2003.
 T. Lahoutte, V. Caveliers, S. M. Camargo, R. Franca, T. Ramadan, E. Veljkovic, J. Mertens,
A. Bossuyt, and F. Verrey, "SPECT and PET amino acid tracer influx via system L (h4F2hc-
hLAT1) and its transstimulation," in J Nucl Med, vol. 45, pp. 1591-6, Sep 2004.
 J. Mertens, V. Kersemans, M. Bauwens, C. Joos, T. Lahoutte, A. Bossuyt, and G. Slegers,
"Synthesis, radiosynthesis, and in vitro characterization of [125I]-2- iodo-L-phenylalanine in a
R1M rhabdomyosarcoma cell model as a new potential tumor tracer for SPECT," in Nucl Med
Biol, vol. 31, pp. 739-46, Aug 2004
 K. Muylle, H. Everaert, J. De Mey, T. Lahoutte, P. R. Franken, and A. Bossuyt, "FDG
accumulation in inguinal herniation mimicking metastatic disease," in Clin Nucl Med, vol. 29, pp.
652-3, Oct 2004.
 K. Poppe, T. Lahoutte, H. Everaert, A. Bossuyt, and B. Velkeniers, "The utility of
multimodality imaging in anaplastic thyroid carcinoma," in Thyroid, vol. 14, pp. 981-2, Nov
2004.
 N. Tran, P. Y. Marie, J. Nloga, F. Mascali, P. Franken, T. Lahoutte, Y. Li, L. Antunes, A. El
Jaafari, D. Bensoussan, J. F. Stoltz, and J. P. Villemot, "Autologous cell based therapy for
treating chronic infarct myocardium," in Clin Hemorheol Microcirc, vol. 33, pp. 263-8, 2005.
 C. Vanhove, T. Lahoutte, M. Defrise, A. Bossuyt, and P. R. Franken, "Reproducibility of left
ventricular volume and ejection fraction measurements in rat using pinhole gated SPECT," in Eur
J Nucl Med Mol Imaging, vol. 32, pp. 211-20, Feb 2005.
 M. Bauwens, T. Lahoutte, K. Kersemans, C. Gallez, A. Bossuyt, and J. Mertens, "Comparison
of the uptake of [123/125I]-2-iodo-D-tyrosine and [123/125I]-2-iodo-L-tyrosine in R1M
rhabdomyosarcoma cells in vitro and in R1M tumor-bearing Wag/Rij rats in vivo," in Nucl Med
Biol, vol. 33, pp. 735-41, Aug 2006.
 C. Weytjens, B. Cosyns, J. D'Hooge, C. Gallez, S. Droogmans, T. Lahoute, P. Franken, and
G. Van Camp, "Doppler myocardial imaging in adult male rats: reference values and
reproducibility of velocity and deformation parameters," in Eur J Echocardiogr, vol. 7, pp. 411-
7, Dec 2006.
 M. Bauwens, M. Keyaerts, T. Lahoutte, K. Kersemans, V. Caveliers, A. Bossuyt, and J.
Mertens, "Intra-individual comparison of the human biodistribution and dosimetry of the D and L
isomers of 2-[123I]iodo-phenylalanine," in Nucl Med Commun, vol. 28, pp. 823-8, Oct 2007.
 M. Bauwens, T. Lahoutte, K. Kersemans, V. Caveliers, A. Bossuyt, and J. Mertens, "D- and
L-[123I]-2-I-phenylalanine show a long tumour retention compared with D- and L-[123I]-2-I-
tyrosine in R1M rhabdomyosarcoma tumour-bearing Wag/Rij rats," in Contrast Media Mol
Imaging, vol. 2, pp. 172-7, Jul 2007.
 S. Droogmans, P. R. Franken, C. Garbar, C. Weytjens, B. Cosyns, T. Lahoutte, V. Caveliers,
M. Pipeleers-Marichal, A. Bossuyt, D. Schoors, and G. Van Camp, "In vivo model of drug-
induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with
echocardiography and correlation with pathology," in Eur Heart J, vol. 28, pp. 2156-62, Sep
2007.
 M. Keyaerts, T. Lahoutte, B. Neyns, V. Caveliers, C. Vanhove, H. Everaert, K. Kersemans,
P. R. Franken, J. Mertens, and A. Bossuyt, "123I-2-iodo-tyrosine, a new tumour imaging agent:
human biodistribution, dosimetry and initial clinical evaluation in glioma patients," in Eur J Nucl
Med Mol Imaging, vol. 34, pp. 994-1002, Jul 2007.
 T. Lahoutte, "Monitoring left ventricular function in small animals," in J Nucl Cardiol, vol. 14,
 B. Cosyns, S. Droogmans, C. Weytjens, T. Lahoutte, G. Van Camp, D. Schoors, PR Franken,
"Effect of streptozotocin-induced diabetes on left ventricular function in adult rats: an in vivo
Pinhole Gated SPECT study," in Cardiovasc Diabetol. 6:30, Oct 15 2007.
 M. Keyaerts, J. Verschueren, T. J. Bos, L. O. Tchouate-Gainkam, C. Peleman, K. Breckpot,
C. Vanhove, V. Caveliers, A. Bossuyt, and T. Lahoutte, "Dynamic bioluminescence imaging for
quantitative tumour burden assessment using IV or IP administration of D: -luciferin: effect on
intensity, time kinetics and repeatability of photon emission," in Eur J Nucl Med Mol Imaging,
Jan 4 2008.
 C. Vanhove, M. Defrise, T. Lahoutte, and A. Bossuyt, "Three-pinhole collimator to improve
axial spatial resolution and sensitivity in pinhole SPECT," in Eur J Nucl Med Mol Imaging, vol.
35, pp. 407-15, Feb 2008.
 V. Cortez-Retamozo, T. Lahoutte, V. Caveliers, LO. Tchouate GainKam, S. Hernot, A.
Packeu, F. De Vos, C. Vanhove, P. De Baetselier, and H. Revets, "99mTc-Labeled Nanobodies:
a new type of targeted probes for imaging antigen expression," in Curr Radiopharm, Vol. 1, pp.
37-41, 2008.
 L. Huang, LO. Tchouate GainKam, V. Caveliers, C. Vanhove, M. Keyaerts, P. De Baetselier,
A. Bossuyt, H. Revets and T. Lahoutte, "SPECT imaging with 99mTc-Labeled EGFR specific
Nanobody for in vivo monitoring of EGFR expression," in Mol Imaging Biol, DOI:
10.1007/s11307-008-0133-8, 2008.
 LO. Tchouate GainKam, L. Huang, V. Caveliers, M. Keyaerts, S. Hernot, I. Vaneycken, C.
Vanhove, H. Revets, P. De Baetselier and T. Lahoutte," Comparison of the biodistribution and
tumor targeting of two 99mTc-Labeled Nanobodies in Mice using pinhole SPECT-microCT," in J
Nucl Med, May;49(5):788-95.
 S. Droogmans , B. Roosens, B. Cosyns, S. Hernot, C. Weytjens, C. Degaillier , C. Garbar, V.
Caveliers, M Pipeleers-Marichal, PR Franken, A Bossuyt, T Lahoutte, D. Schoors , G. Van
Camp. Echocardiographic and histological of age related valvular changes in normal rats. in
Ultrasound Med Biol. 2008 Dec 26.
 C. Weytjens, PR. Franken, J. D'hooge , S. Droogmans, B. Cosyns, T. Lahoutte, G. Van
Camp. Doppler myocardial imaging in the diagnosis of early systolic left ventricular dysfunction
in diabetic rats. in Eur J Echocardiogr. 2008 May;9(3):326-33.
 C. Vanhove , M. Defrise , A. Bossuyt, T. Lahoutte. Improved quantification in single-pinhole
and multiple-pinhole SPECT using micro-CT information. in Eur J Nucl Med Mol I. 2009 Feb
14.
 L. Baeyens , S. Bonné , T. Bos, I. Rooman , C. Peleman ,T. Lahoutte, M. German, H.
Heimberg , L. Bouwens. Notch signaling as gatekeeper of rat acinar-to-beta cell conversion in
vitro. in Gastroenterology. 2009 Jan 26.
 I. Willekens, T. Lahoutte, N. Buls, C. Vanhove, R. Deklerck, A. Bossuyt, J. de Mey. Time-
Course of Contrast Enhancement in Spleen and Liver with Exia 160, Fenestra LC, and VC. in Mol
Imaging Biol. 2009 Mar-Apr;11(2):128-35.
 C. Weytjens, J D'hooge , S Droogmans , A Van den Bergh, B Cosyns, T Lahoutte, P
Herijgers, G Van Camp. Influence of heart rate reduction on Doppler myocardial imaging
parameters in a small animal model. in Ultrasound Med Biol. 2009 Jan;35(1):30-5
 Droogmans S, Roosens B, Cosyns B, Degaillier C, Hernot S, Weytjens C, Garbar C,
Caveliers V, Pipeleers-Marichal M, Franken PR, Lahoutte T, Schoors D, Van Camp
G.Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and
histopathological study. in Am J Physiol Heart Circ Physiol. 2009 Apr 3
 Droogmans S, Roosens B, Cosyns B, Degaillier C, Hernot S, Weytjens C, Garbar C,
Caveliers V, Pipeleers-Marichal M, Franken PR, Bossuyt A, Schoors D, Lahoutte T, Van
Camp G. Dose Dependency and Reversibility of Serotonin-Induced Valvular Heart Disease in
Rats. in Cardiovasc Toxicol. 2009 Jul 16.

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