Tony Lahoutte Profil professionnel
Charge de cours (Docent) 10% ZAP, VUB - 1/10/2006
Charge de cours 5%, UMH – 1/10/2009 – 30-9-2014
Chef de Clinique en Médecine Nucléaire, UZ Brussel - 1/10/
Maître de Recherches Cliniques du Fonds de la Recherche Scientifique Flandre, 1/10/2007
Chef de recherche du labo « in vivo cellular and molecular imaging» à la VUB, 1/10/2006
1999 : Laboratory Animal Science, UGent
2000 : Master in Medical and Pharmaceutical Research, VUB
2004 : Thèse de doctorat en Sciences Médicales, VUB
2005 : Médecin Specialist en Médecine Nucléaire
V. Caveliers, H. Everaert, T. Lahoutte, L. O. Dierickx, C. S. John, and A. Bossuyt, Labelled
sigma receptor ligands: can their role in neurology and oncology be extended?, in Eur J Nucl Med, vol. 28, pp. 133-5, Feb 2001.
L. O. Dierickx, T. Lahoutte, P. Deron, V. Caveliers, C. Vanhove, H. Everaert, and A. Bossuyt, Diagnosis of recurrent head and neck squamous cell carcinoma with 3-[123I]iodo-L- alpha-methyltyrosine SPET,in Eur J Nucl Med, vol. 28, pp. 282-7, Mar 2001.
T. Lahoutte, V. Caveliers, L. Dierickx, M. Vekeman, H. Everaert, J. Mertens, and A. Bossuyt, "In vitro characterization of the influx of 3-[125I]iodo-L-alpha-methyltyrosine and 2- [125I]iodo-L-tyrosine into U266 human myeloma cells: evidence for system T transport," in Nucl Med Biol, vol. 28, pp. 129-34, Feb 2001.
V. Caveliers, H. Everaert, C. S. John, T. Lahoutte, and A. Bossuyt, "Sigma receptor
scintigraphy with N-[2-(1'-piperidinyl)ethyl]-3-(123)I-iodo-4-methoxybenzamide of patients with suspected primary breast cancer: first clinical results," in J Nucl Med, vol. 43, pp. 1647-9, Dec 2002.
T. Lahoutte, V. Caveliers, P. R. Franken, A. Bossuyt, J. Mertens, and H. Everaert, "Increased
tumor uptake of 3-(123)I-Iodo-L-alpha-methyltyrosine after preloading with amino acids: an in vivo animal imaging study," in J Nucl Med, vol. 43, pp. 1201-6, Sep 2002.
L. O. Dierickx, H. Everaert, P. Deron, M. Voordeckers, T. Lahoutte, and A. Bossuyt,
"Evaluation of the response to therapy of head and neck squamous cell carcinoma by using 3-
[123I]iodo-L-alpha-methyl tyrosine and single photon emission tomography," in Nucl Med Commun, vol. 24, pp. 633-41, Jun 2003.
H. Everaert, H. De Boeck, K. Muylle, T. Lahoutte, and A. Bossuyt, "Hypertrophic osteitis of
the clavicle," in Clin Nucl Med, vol. 28, pp. 990-1, Dec 2003.
H. Everaert, C. Vanhove, T. Lahoutte, K. Muylle, V. Caveliers, A. Bossuyt, and P. R. Franken, "Optimal dose of 18F-FDG required for whole-body PET using an LSO PET camera," in Eur J Nucl Med Mol Imaging, vol. 30, pp. 1615-9, Dec 2003.
T. Lahoutte, J. Mertens, V. Caveliers, P. R. Franken, H. Everaert, and A. Bossuyt,
"Comparative biodistribution of iodinated amino acids in rats: selection of the optimal analog for oncologic imaging outside the brain," in J Nucl Med, vol. 44, pp. 1489-94, Sep 2003.
T. Lahoutte, V. Caveliers, S. M. Camargo, R. Franca, T. Ramadan, E. Veljkovic, J. Mertens, A. Bossuyt, and F. Verrey, "SPECT and PET amino acid tracer influx via system L (h4F2hc- hLAT1) and its transstimulation," in J Nucl Med, vol. 45, pp. 1591-6, Sep 2004.
J. Mertens, V. Kersemans, M. Bauwens, C. Joos, T. Lahoutte, A. Bossuyt, and G. Slegers,
"Synthesis, radiosynthesis, and in vitro characterization of [125I]-2- iodo-L-phenylalanine in a R1M rhabdomyosarcoma cell model as a new potential tumor tracer for SPECT," in Nucl Med Biol, vol. 31, pp. 739-46, Aug 2004
K. Muylle, H. Everaert, J. De Mey, T. Lahoutte, P. R. Franken, and A. Bossuyt, "FDG
accumulation in inguinal herniation mimicking metastatic disease," in Clin Nucl Med, vol. 29, pp. 652-3, Oct 2004.
K. Poppe, T. Lahoutte, H. Everaert, A. Bossuyt, and B. Velkeniers, "The utility of
multimodality imaging in anaplastic thyroid carcinoma," in Thyroid, vol. 14, pp. 981-2, Nov 2004.
N. Tran, P. Y. Marie, J. Nloga, F. Mascali, P. Franken, T. Lahoutte, Y. Li, L. Antunes, A. El Jaafari, D. Bensoussan, J. F. Stoltz, and J. P. Villemot, "Autologous cell based therapy for treating chronic infarct myocardium," in Clin Hemorheol Microcirc, vol. 33, pp. 263-8, 2005.
C. Vanhove, T. Lahoutte, M. Defrise, A. Bossuyt, and P. R. Franken, "Reproducibility of left
ventricular volume and ejection fraction measurements in rat using pinhole gated SPECT," in Eur J Nucl Med Mol Imaging, vol. 32, pp. 211-20, Feb 2005.
M. Bauwens, T. Lahoutte, K. Kersemans, C. Gallez, A. Bossuyt, and J. Mertens, "Comparison
of the uptake of [123/125I]-2-iodo-D-tyrosine and [123/125I]-2-iodo-L-tyrosine in R1M rhabdomyosarcoma cells in vitro and in R1M tumor-bearing Wag/Rij rats in vivo," in Nucl Med Biol, vol. 33, pp. 735-41, Aug 2006.
C. Weytjens, B. Cosyns, J. D'Hooge, C. Gallez, S. Droogmans, T. Lahoute, P. Franken, and G. Van Camp, "Doppler myocardial imaging in adult male rats: reference values and reproducibility of velocity and deformation parameters," in Eur J Echocardiogr, vol. 7, pp. 411- 7, Dec 2006.
M. Bauwens, M. Keyaerts, T. Lahoutte, K. Kersemans, V. Caveliers, A. Bossuyt, and J. Mertens, "Intra-individual comparison of the human biodistribution and dosimetry of the D and L isomers of 2-[123I]iodo-phenylalanine," in Nucl Med Commun, vol. 28, pp. 823-8, Oct 2007.
M. Bauwens, T. Lahoutte, K. Kersemans, V. Caveliers, A. Bossuyt, and J. Mertens, "D- and
L-[123I]-2-I-phenylalanine show a long tumour retention compared with D- and L-[123I]-2-I- tyrosine in R1M rhabdomyosarcoma tumour-bearing Wag/Rij rats," in Contrast Media Mol Imaging, vol. 2, pp. 172-7, Jul 2007.
S. Droogmans, P. R. Franken, C. Garbar, C. Weytjens, B. Cosyns, T. Lahoutte, V. Caveliers, M. Pipeleers-Marichal, A. Bossuyt, D. Schoors, and G. Van Camp, "In vivo model of drug-
induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology," in Eur Heart J, vol. 28, pp. 2156-62, Sep 2007.
M. Keyaerts, T. Lahoutte, B. Neyns, V. Caveliers, C. Vanhove, H. Everaert, K. Kersemans, P. R. Franken, J. Mertens, and A. Bossuyt, "123I-2-iodo-tyrosine, a new tumour imaging agent: human biodistribution, dosimetry and initial clinical evaluation in glioma patients," in Eur J Nucl Med Mol Imaging, vol. 34, pp. 994-1002, Jul 2007.
T. Lahoutte, "Monitoring left ventricular function in small animals," in J Nucl Cardiol, vol. 14,
B. Cosyns, S. Droogmans, C. Weytjens, T. Lahoutte, G. Van Camp, D. Schoors, PR Franken,
"Effect of streptozotocin-induced diabetes on left ventricular function in adult rats: an in vivo Pinhole Gated SPECT study," in Cardiovasc Diabetol. 6:30, Oct 15 2007.
M. Keyaerts, J. Verschueren, T. J. Bos, L. O. Tchouate-Gainkam, C. Peleman, K. Breckpot, C. Vanhove, V. Caveliers, A. Bossuyt, and T. Lahoutte, "Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of D: -luciferin: effect on intensity, time kinetics and repeatability of photon emission," in Eur J Nucl Med Mol Imaging, Jan 4 2008.
C. Vanhove, M. Defrise, T. Lahoutte, and A. Bossuyt, "Three-pinhole collimator to improve
axial spatial resolution and sensitivity in pinhole SPECT," in Eur J Nucl Med Mol Imaging, vol. 35, pp. 407-15, Feb 2008.
V. Cortez-Retamozo, T. Lahoutte, V. Caveliers, LO. Tchouate GainKam, S. Hernot, A. Packeu, F. De Vos, C. Vanhove, P. De Baetselier, and H. Revets, "99mTc-Labeled Nanobodies: a new type of targeted probes for imaging antigen expression," in Curr Radiopharm, Vol. 1, pp. 37-41, 2008.
L. Huang, LO. Tchouate GainKam, V. Caveliers, C. Vanhove, M. Keyaerts, P. De Baetselier, A. Bossuyt, H. Revets and T. Lahoutte, "SPECT imaging with 99mTc-Labeled EGFR specific Nanobody for in vivo monitoring of EGFR expression," in Mol Imaging Biol, DOI: 10.1007/s11307-008-0133-8, 2008.
LO. Tchouate GainKam, L. Huang, V. Caveliers, M. Keyaerts, S. Hernot, I. Vaneycken, C. Vanhove, H. Revets, P. De Baetselier and T. Lahoutte," Comparison of the biodistribution and tumor targeting of two 99mTc-Labeled Nanobodies in Mice using pinhole SPECT-microCT," in J Nucl Med, May;49(5):788-95.
S. Droogmans , B. Roosens, B. Cosyns, S. Hernot, C. Weytjens, C. Degaillier , C. Garbar, V. Caveliers, M Pipeleers-Marichal, PR Franken, A Bossuyt, T Lahoutte, D. Schoors , G. Van Camp. Echocardiographic and histological of age related valvular changes in normal rats. in Ultrasound Med Biol. 2008 Dec 26.
C. Weytjens, PR. Franken, J. D'hooge , S. Droogmans, B. Cosyns, T. Lahoutte, G. Van Camp. Doppler myocardial imaging in the diagnosis of early systolic left ventricular dysfunction in diabetic rats. in Eur J Echocardiogr. 2008 May;9(3):326-33.
C. Vanhove , M. Defrise , A. Bossuyt, T. Lahoutte. Improved quantification in single-pinhole
and multiple-pinhole SPECT using micro-CT information. in Eur J Nucl Med Mol I. 2009 Feb 14.
L. Baeyens , S. Bonné , T. Bos, I. Rooman , C. Peleman ,T. Lahoutte, M. German, H. Heimberg , L. Bouwens. Notch signaling as gatekeeper of rat acinar-to-beta cell conversion in vitro. in Gastroenterology. 2009 Jan 26.
I. Willekens, T. Lahoutte, N. Buls, C. Vanhove, R. Deklerck, A. Bossuyt, J. de Mey. Time-
Course of Contrast Enhancement in Spleen and Liver with Exia 160, Fenestra LC, and VC. in Mol Imaging Biol. 2009 Mar-Apr;11(2):128-35.
C. Weytjens, J D'hooge , S Droogmans , A Van den Bergh, B Cosyns, T Lahoutte, P Herijgers, G Van Camp. Influence of heart rate reduction on Doppler myocardial imaging parameters in a small animal model. in Ultrasound Med Biol. 2009 Jan;35(1):30-5
Droogmans S, Roosens B, Cosyns B, Degaillier C, Hernot S, Weytjens C, Garbar C, Caveliers V, Pipeleers-Marichal M, Franken PR, Lahoutte T, Schoors D, Van Camp G.Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. in Am J Physiol Heart Circ Physiol. 2009 Apr 3
Droogmans S, Roosens B, Cosyns B, Degaillier C, Hernot S, Weytjens C, Garbar C, Caveliers V, Pipeleers-Marichal M, Franken PR, Bossuyt A, Schoors D, Lahoutte T, Van Camp G. Dose Dependency and Reversibility of Serotonin-Induced Valvular Heart Disease in Rats. in Cardiovasc Toxicol. 2009 Jul 16.
1.0 INCLUSION CRITERIA Patients, male or female, >18 years of agePatients who present electively with in-stent restenosis of a previously placed stent documented by coronary The patient has stable or unstable angina, and/or clinical evidence of ischemia (ECG, exercise test, etc)The patient is able and wil ing to conform to the requirements of the study and voluntarily signs an Informed Co
Casitas : The Myth of Physical Requisition The Penn Central test never purported to capture the entirety of the rich landscape (or waterscape) of takings cases -- more on that point at the end of this presentation. The result in Casitas underscores that important point. But, beyond that, this particular case, Casitas , has been plagued by important misunderstandings in the way it has bee