Cv_eng_jan10

Giulia Mollica
Curriculum vitae

PhD in Chemical Sciences
Laboratoire Chimie Provence, équipe SACS Case 512 Campus Scientifique St Jérôme Université de Provence Avenue Escadrille Normandie Niémen
PERSONAL
Born June 27th 1978 in Livorno, Italy.
One child.
EDUCATION
• PhD, Chemistry (Physical Chemistry), Nuclear Magnetic Resonance (Solid State NMR), January
2007. Thesis: “Structure and dynamic analysis of complex polymeric systems by means of high and
low resolution solid-state NMR”. Supervisor: Prof. C.A. Veracini.
• Graduated in Chemistry (Physical Chemistry), April 2003. Thesis: “Study of drugs and drug-to-
polymer complexes by means of solid state NMR: structure and dynamics of Ibuprofen-Eudragit systems”. Supervisor: Prof. C. A. Veracini, Dr. M. Geppi.
RESEARCH EXPERIENCE
• January 2002-December 2008: Solid-state NMR spectroscopy within Prof. C.A. Veraciniʼs NMR
Spectroscopy group, Dipartimento di Chimica e Chimica Industriale, Università di Pisa. -Characterization of pharmaceutical compounds through solid-state NMR. -Solid-state NMR dynamic and structural characterization of composite polymeric compounds. -Investigation of solid biological samples (i.e. silkworm cocoons) through the application of high- and low-resolution solid-state NMR techniques. -Structural study of organic/inorganic multicomponent materials by means of multinuclear solid-state NMR techniques. • Post-doctoral researcher at the University of Pisa (2007-2008). Scientific interests: solid-state
NMR of pharmaceuticals, biomacromolecules, and composite materials; nuclear relaxation and dynamics of polymers; development and application of new solid-state NMR pulse sequences. • June-September 2008: visiting post-doc researcher at the University of California, Irvine (CA, USA),
under the supervision of Prof. R. W. Martin. Characterization of eumelanin samples by means of solid-state NMR recoupling techniques. • October 2005-April 2006: visiting student at the University of Southampton, (U.K.), under the
supervision of prof. M. H. Levitt. -Development of new pulse sequences for the measurements of internuclear distances in multi-spin systems by means of zero-quantum recoupling techniques.
• June-August 2005: visiting student at the Université de Provence, Jeune Equipe TRACES,
Marseille (France), under the supervision of prof. S. Caldarelli.
-Quantitative analysis on mixtures of either organic or inorganic natural compounds by means of solid-
state NMR.
PRESENT POSITION

Marie Curie fellow under the FP7 (Intra European Fellowship, January 2010-December 2011). Development of new Nuclear Magnetic Resonance methods for the structural study of solid and semi-solid systems. Solid state NMR structural characterization of synthetic and natural melanin. PUBLICATIONS
1. L. Calucci, L. Galleschi, M. Geppi, G. Mollica. Structure and dynamics of flour by solid state NMR:
effects of hydration and wheat aging. Biomacromolecules 5:1536-1544 (2004).
2. M. Geppi, S. Guccione, G. Mollica, R. Pignatello, C.A. Veracini. Molecular properties of Ibuprofen and
its solid dispersions with Eudragit RL100 studied by Solid-State Nuclear Magnetic Resonance. Pharm. Res. 22:1544-1555 (2005).
3. G. Di Colo, A. Baggiani, Y. Zambito, G. Mollica, M. Geppi, M.F. Serafini. A new hydrogel for the
extended and complete prednisolone release in the GI tract. Int. J. Pharm. 310:154-161 (2006).
4. G. Mollica, M. Geppi, R. Pignatello, C.A. Veracini. Molecular properties of Flurbiprofen and its solid
dispersions with Eudragit RL100 studied by high and low resolution solid-state NMR. Pharm. Res, 23:2129-2140 (2006).
5. I. Marin-Montesinos, G. Mol ica, M. Carravetta, A. Gansmul er, G. Pileio, M. Bechmann, A. Sebald, M.
H. Levitt. Truncated Dipolar Recoupling in Solid-State Nuclear Magnetic Resonance, Chem. Phys. Lett. 432:572-578 (2006).
6. V. Castelvetro, M. Geppi, S. Giaiacopi, G. Mollica. Cotton fibers encapsulated with homo- and block-
copolymers: synthesis by the atom transfer radical polymerization grafting-from technique and solid-state NMR dynamic characterization, Biomacromolecules 8:498-508 (2007).
7. M. Geppi, G. Mol ica, S. Borsacchi, M. Marini, M. Tosel i, F. Pilati. Solid-state NMR characterization of
PE-PEG/silica hybrid materials prepared by microwave-assisted sol-gel process, J. Mater. Res. 22:3516-3525 (2007).
8. C. Zaino, Y. Zambito, G. Mol ica, M. Geppi, M.F. Serafini, V. Carel i, G. Di Colo A novel polyelectrolyte
complex (PEC) hydrogel for controlled drug delivery to the distal intestine, Open Drug Del. J. 1:68-75 (2007)
9. M. Marini, M. Tosel i, S. Borsacchi, G. Mol ica, M. Geppi, F. Pilati. Facile synthesis of core-shell
organic-inorganic hybrid nanoparticles with amphiphilic polymer shell by one-step sol-gel reactions, J. Polym. Sci. Polym. Chem.46:1699-1709 (2008).
10. G. Pileio, S. Mamone, G. Mol ica, I. Marin-Montesinos, A. Gansmul er, M. Carravetta, S. Brown, M. H.
Levitt. Estimation of internuclear couplings in the solid-state NMR of multiple-spin systems. Selective spin echoes and off-magic-angle spinning, Chem. Phys. Lett. 456:116-121 (2008).
11. M. Geppi, G. Mol ica, S. Borsacchi, C.A. Veracini. Solid-state NMR studies of pharmaceutical systems.
Appl. Spectrosc. Rev. (2008), 43: 202-302 (2008).
12. M. Geppi, S. Borsacchi, G. Mollica. Solid-state NMR of organic/inorganic multicomponent materials.
Encyclopedia of NMR, eds R. K. Harris and R. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm1014. Published 15th October 2008.
13. M. Geppi, S. Borsacchi, G. Mollica, C. A. Veracini. Applications of solid-state NMR to the study of
organic/inorganic multicomponent materials. Appl. Spectr. Rev., 44:1-89 (2009).
14. M. Geppi, G. Mol ica, S. Borsacchi, S. Cappel ozza. Proton spin-lattice relaxation in silkworm cocoons:
physisorbed water and serine side-chain motions. J. Phys. Chem B. accepted (2010). PRESENTATIONS AT INTERNATIONAL CONFERENCES
1. X Chianti Workshop on Magnetic Resonance, S. Miniato (Italy), 05/2003: “Study of structural and dynamic behaviour of Ibuprofen and its complexes with Eudragit® RL100 by means of solid state NMR”, M. Geppi, S. Guccione, G. Mol ica, R. Pignatel o, C.A. Veracini. 2. 8th Gluten Workshop, Viterbo (Italy), 2003: “Use of 13C and 1H solid state NMR techniques to probe the changes induced in flour by accelerated aging of bread wheat seeds”, L. Calucci, C. Forte, L. Gal eschi, M. Geppi, S. Ghiringhel i, G. Mol ica. 3. 17th EENC, Lil e (France), 5-11/09/2004: “Study of structural and dynamic behaviour of Ibuprofen and its solid dispersions with Eudragit RL100 by means of solid state NMR”, M. Geppi, S. Guccione, G. Mol ica, R. Pignatel o, C.A. Veracini. 4. 34th GIDRM, Tramariglio, Alghero (Italy), 21-24/09/2004: a) “Use of 13C and 1H solid state NMR techniques to probe the changes induced in flour by accelerated aging of bread wheat seeds”, L. Calucci, M. Geppi, G. Mol ica; b) “Solid state NMR of drugs: a study of non-steroidal anti-inflammatory drugs and their dispersions with polymeric carriers”, M. Geppi, S. Guccione, G. Mollica, R. Pignatello, C.A. Veracini. 5. 4th Conference on Field Cycling NMR Relaxometry, Torino (Italy), 05/2005: “Dynamics of amorphous polymers through a unified analysis of multi-frequency 1H and 13C spin-lattice relaxation times”, M. Geppi, C. Forte, M. Malvaldi, G. Mol ica, C.A. Veracini. 6. Ampere XIII NMR School, Zakopane (Poland), 5-10/06/2005: “Structural and dynamic behaviour of Ibuprofen, Flurbiprofen and their solid dispersions with Eudragit RL100 by means of high and low resolution solid state NMR”, G. Mollica, M. Geppi, C.A. Veracini. 7. SCI - Divisione di Chimica Fisica - 34° Congresso Nazionale, Siena (Italy), 06/2005: a) “Dynamics of amorphous polymers through a unified analysis of multi-frequency 1H and 13C spin-lattice relaxation times”, M. Geppi, C. Forte, M. Malvaldi, G. Mollica, C. A. Veracini; b) “Structural and dynamic behaviour of Ibuprofen, Flurbiprofen and their solid dispersions with a polymeric carrier by solid state NMR”, M. Geppi, G. Mol ica, C.A. Veracini, R. Pignatel o, S. Guccione. 8. Matter, Materials and Devices Meeting, Genova (Italy), 2005: “Effects of wheat aging on flour properties as investigated by high and low resolution 1H NMR techniques”, L. Calucci, C. Forte, M. Geppi, G. Mol ica, S. Pizzanel i. 9. SMASH Conference, Verona (Italy), 25-28/09/2005: “Structural and dynamic behaviour of Ibuprofen, Flurbiprofen and their solid dispersions with Eudragit RL100 by means of high and low resolution solid state NMR”, G. Mollica, M. Geppi, S. Guccione, R. Pignatello, C. A. Veracini. 10. 4th Alpine Conference on Solid-State NMR, Chamonix (France), 11-15/09/2005: “Dynamics of amorphous polymers through a unified analysis of multi-frequency 1H and 13C spin-lattice relaxation times”, G. Mollica, M. Geppi, C. Forte, M. Malvaldi, C.A. Veracini. 11. 47th ENC, Asilomar, CA (USA), 23-28/04/2006: “Towards the measurement of individual internuclear distances in the magic-angle-spinning NMR of homonuclear multispin systems”, l. Marin Montesinos, G. Mol ica, A. Gansmuller, M. Carravetta, M. H. Levitt. 12. 36th GIDRM, Vietri (Italy), 20-23/09/2006: a) ”Dynamic behaviour of silkworm cocoon silks by means of nuclear relaxation properties in the solid state”, M. Geppi, S. Borsacchi, S. Cappellozza, D. Catalano, V. Ierardi, G. Mol ica; b) “Structural and dynamic behaviour of Flurbiprofen and its solid dispersions with Eudragit RL100 by means of high- and low-resolution solid-state NMR”, G. Mollica, M. Geppi, R. Pignatel o, C.A. Veracini; c) “Dynamics of amorphous polymers through a multi-nuclear and multi-frequency unified analysis of spin-lattice relaxation times”, G. Mollica, C. Forte, M. Geppi, C.A. Veracini. 13. 2006 MRS Fall Meeting, Boston, MA (USA), 27/11-1/12/2006: a) “Cotton Fibers Encapsulated with Homo and Block- Copolymers by means of ATRP Grafting-From Technique: a Solid State NMR Study”, G. Mollica, V. Castelvetro, M. Geppi, S. Giaiacopi; b) “Dynamics of amorphous polymers through a unified analysis of multi-frequency 1H and 13C spin-lattice relaxation times”, G. Mollica, M. Geppi, C. Forte, M. Malvaldi, C.A. Veracini; c) “Dynamic behaviour of cocoon silks produced by Bombyx Mori by means of nuclear relaxation properties in the solid state”, M. Geppi, S. Borsacchi, S. Cappel ozza, D. Catalano, V. Ierardi, G. Mol ica. 14. XI Chianti Workshop on Magnetic Resonance, Val ombrosa (Italy), 3-6/06/2007: a) “High- and lowresolution solid-state NMR characterization of chitosan vesicles”, G. Mollica, M. Geppi, Y. Zambito, G. Di Colo, C.A. Veracini; b) “Nuclear relaxation mechanisms in silkworm cocoons”, M. Geppi, S. Borsacchi, G. Mollica, S. Cappellozza, C.A. Veracini. 15. 5th Alpine Conference on Solid-State NMR, Chamonix (France), 9-13/09/2007: a) “Nuclear relaxation mechanisms in silkworm cocoons”, G. Mol ica, M. Geppi, S. Borsacchi, S. Cappel ozza, C.A. Veracini; b) “Multinuclear study of PE/PEG/silica hybrid materials prepared by sol-gel processes”, S. Borsacchi, M. Geppi, G. Mol ica, M. Marini, M. Tosel i, F. Pilati. 16. 37th National Congress on Magnetic Resonance, Verbania, 12-15/09/2007: a) “Multinuclear solid- state NMR study of PE-PEG/silica hybrid materials prepared by sol-gel processes”, S. Borsacchi, M. Geppi, G. Mol ica, M. Marini, M. Tosel i, F. Pilati; b) “Nuclear relaxation mechanisms in silkworm cocoons”, G. Mollica, M. Geppi, S. Borsacchi, S. Cappellozza, C.A. Veracini; c) ”High- and low-resolution solid-state NMR characterization of chitosans vesicles”, G. Mollica, M. Geppi, Y. Zambito, G. Di Colo; d) ”Cotton fibers- encapsulated with homo- and block-copolymers by means of ATRP grafting-from technique: a solid-state NMR study”, G. Mollica, M. Geppi, V. Castelvetro, S. Giaiacopi. 17. Innovation in Drug Delivery - from Biomaterials to Devices, Napoli, (Italy), 30/9-3/10/2007: “A novel polyelectrolyte complex (PEC) hydrogel for controlled drug delivery to the colon”, C. Zaino, Y. Zambito, M. Geppi, G. Mol ica, M.F. Serafini, V. Carel i, G. Di Colo. 18. XXXVII Congresso Nazionale di Chimica Fisica, Camogli, (Italy), 24-29/02/2008: a) “Multinuclear solidstate NMR study of PE-PEG/silica hybrid materials prepared by sol-gel processes”, S. Borsacchi, M. Geppi, G. Mol ica, M. Marini, M. Tosel i, F. Pilati; b) “Nuclear relaxation mechanisms in silkworm cocoons”, M. Geppi, G. Mollica, S. Borsacchi, S. Cappellozza, C.A. Veracini; c) ”High- and low-resolution solid-state NMR characterization of chitosans vesicles”, G. Mol ica, M. Geppi, Y. Zambito, G. Di Colo; d) ”Cotton fibers encapsulated with homo- and block-copolymers by means of ATRP grafting-from technique: a solid-state NMR study”, G. Mollica, M. Geppi, V. Castelvetro, S. Giaiacopi. 19. 38th GIDRM, Brixen (Italy) 10-13/09/2008: a) “The use of solid-state NMR in the study of drugs”, G. Mol ica, M. Geppi, S. Borsacchi, C. A. Veracini; b) “Organic-Inorganic Multicomponent Matrials (OIMM): the role of solid-state NMR for the study of this general category of systems”, S. Borsacchi, M. Geppi, G. Mol ica, C. A. Veracini; c) “Orientational order of fluorinated and borinated liquid crystals by 13C, 11B, and 19F NMR techniques”, L. Calucci, M. Geppi, S. Borsacchi, A. Marini, G. Mollica, S. Urban, J. Czub.

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