Introduction and Organization
Tokyo Medical College. Dr. Kunita moved here from
University of Basel, and Dr. Matsusaka from
Department of Pathology and Diagnostic Pathology is
Metropolitan Cancer and Infectious Disease Center,
responsible for the practice of diagnostic pathology,
education, and research in conjunction with Division
Four postgraduate students (Hibiya, Tanaka,
of Diagnostic Pathology of the University Hospital*.
Sung, Yoshida) finished the course and received Ph.D.
Our aim is the construction of “pathology as clinical
In the new fiscal year, 2011, five new students will
medicine” as well as “next-generation pathology for
enter the postgraduate course, and there will be 16
postgraduates (including one foreign student).
Dr. Shibahara and Dr. Morikawa were working
We are responsible for the pathology practice of
as a visiting researcher in Mayo and Harvard
the University Hospital, and carrying forward the
University, USA, respectively.Dr. Nakaya moved to
morphology-based research targeting human diseases.
As for the education of Pathology, we take charge of
related to medical treatment (DRMT) has been in
the following courses for the medical students;
operation since September 2005, and we continue to
General Pathology course for the 1st grade students in
be a member of the autopsy inspection of the project.
collaboration with Department of Molecular
Pathology, Systemic Pathology for the 2nd grade,
Teaching activities
Clinical Clerkship for the 3rd grade, and Bedside-learning (BSL) for the 4th grade students,
We take on General Pathology Course for the 1st grade
respectively. Programs for postgraduates and junior
of undergraduate students, especially in its
residents are also included in our education activities.
morphological field. The course program and lecture
We held 100th Annual Meeting of Japanese
notes are open to the public and available in UT Open
Society of Pathology from April, 28-30, 2011 at
Yokohama Pacifico (President Fukayama, Vice
Each class of Systemic Pathology Course and
President: Dr. Miyazono), with wish to recover from
exercises are held in parallel with that of Systemic
the Great East Japan Earthquake of March, 11, 2011,
Medicine Course. Handouts are available in every half
although we had to reduce the number of programs.
course of the pathological exercises, and all slides
The memorial ceremony was held on April 29, to
used in the course are accessible on our website as
celebrate the 100th Anniversary of the Japanese
virtual slides (digital images of the slides).
Society of Pathology in the very presence of Price
Clinical clerkship for the 3rd grade, and BSL for
the 4th grade are carried out. In BSL, following
We had to postpone the Extension Lecture for
courses are included; autopsy pathologic practices
Citizens “Autopsy and Medical Safety” on May 1, but
with a case presentation for paired students, surgical
could hold it on September 23 at Sanjo Kaikan, the
pathologic practices using various tumor sections, and
University of Tokyo. The contents were included in
a tour of the pathology laboratory. The past
the book, “Autopsy in Medical Practice”.
examinations for graduation and Systemic Pathology
for the second grade students and are referred to the
Clinical activities (diagnostic pathology and autopsy)
We also have charge of the lecture series of
tumor pathology for the Cancer Profession Training
Together with Division of Diagnostic Pathology, we
are responsible for the pathologic diagnosis and
autopsy in the University Hospital (see the
Research activities
corresponding section of Division of Diagnostic
The first major theme is “chronic inflammation and
Surgical pathology conferences are regularly held
neoplasms”, especially Epstein-Barr virus (EBV)
with each clinical division, and the cases of various
associated gastric carcinoma (GC) (Drs. Uozaki,
tumors, including thoracic organs, liver and pancreato-
Ushiku, Hino, Shinozaki, Matsusaka, and Kunita). We
biliary tract, urology, gynecology, breast, and
are focusing on mechanisms of abnormalties in CpG
orthopedics, as well as biopsy cases of lkidney, skin
island methylation and microRNA molecules in the
development and progression of EBV-associated GC
Clinico-pathological conferences (CPCs) for two
autopsy cases are held every month in the hospital.
The second major theme is ‘traslational research
Together with weekly autopsy conferences, they are
pathology’. We are engaged in search of target
useful for the education of clinical residents. Digest
molecules for cancer therapy by global analysis of
version of CPC slides is now open in the hospital, and
expression profiles of various cancers, in collaboration
we also started e-learning program for interns to
with Research Center for Advanced Science and
facilitate the understanding of the CPC contents.
Technology (RCAST), the University of Tokyo. In
A model project for the survey analysis of deaths
addition, we take part in a global COE program,
Comprehensive Center of Education and research
RJ, Maeda D, Chen E, Jeng YM, Wang TL, Shih
for Chemical Biology of the Diseases, in which we
IeM. Mutation and loss of expression of ARID1A
are investigating the morphological analysis of gene
in uterine low-grade endometrioid carcinoma. Am
expression abnormalities of the key molecules for
several diseases (Dr. Yamauchi). We discovered
(5) Hanamura K, Tojo A, Kinugasa S, Asaba K,
expression of gastric type claudin 18 in intraepithelial
Onozato ML, Uozaki H, Fukayama M, Fujita T.
neioplasms of biliary and pancreatic ducts during the
Detection of myeloperoxidase in membranous
screening of cancer specific molecules (Drs. Shibahara,
nephropathy-like deposits in patients with
shinozaki) and pointed out the importance of gastric
anti-neutrophil cytoplasmic antibody-associated
metaplasia for the development of cancer (Shinozaki
glomerulonephritis. Hum Pathol. 2011; 42(5):
Dr. Ishikawa’s group is developing the methods
(6) Inoue H, Yamazaki S, Shimizu M, Uozaki H,
analyzing genome information precisely to establish a
Goto T, Ohnishi S, Koike K. Liver injury induced
by the Japanese herbal drug kamishoyosan.
The third theme is to re-evaluate the disease
Gastroenterol Hepatol (N Y). 2011; 7: 692-5.
entities and tumor entities from the standpoint of
(7) Ishida M, Gonoi W, Hagiwara K, Takazawa Y,
classical histopathology. Dr. Ushiku reported a
Akahane M, Fukayama M, Ohtomo K. Hypostasis
micro-papillary subtype of gastric carcinoma, with
in the heart and great vessels of non-traumatic
high frequency of lymph node metastasis (ref. 32) . Dr.
in-hospital death cases on postmortem computed
Maeda discovered a subtype of ovarian tumor,
tomography: relationship to antemortem blood
microcystic stromal tumor of ovary, which was
tests. Leg Med (Tokyo). 2011; 13(6): 280-5.
characterized by beta catenin mutation (ref. 16).
(8) Ishida M, Gonoi W, Hagiwara K, Takazawa Y,
pathology practice will be described in Diagnostic
Postmortem changes of the thyroid on computed
tomography. Leg Med (Tokyo). 2011; 13(6):
References
(9) Isagawa T, Nagae G, Shiraki N, Fujita T, Sato N,
(including those of Diagnostic Pathology Division)
methylation profiling of embryonic stem cell
(1) Abe H, Morikawa T, Araki A, Shima T,
differentiation into the three germ layers. PLoS
IgG4-related periureteral fibrosis presenting as a
(10) Kitano K, Watanabe K, Emoto N, Kage H,
unilateral ureteral mass. Pathol Res Pract. 2011;
Nakajima J, Goto A, Fukayama M, Yatomi Y,
(2) Fujiwara M, Kashima TG, Kunita A, Kii I,
Ohishi N, Takai D. CpG island methylation of
Komura D, Grigoriadis AE, Kudo A, Aburatani H,
microRNAs is associated with tumor size and
recurrence of non-small-cell lung cancer. Cancer
suppresses cell migration and metastasis of
osteosarcoma, Tumour Biol. 2011; 32(3): 611-22.
(11) Kagoya Y, Takahashi T, Nannya Y, Shinozaki A,
(3) Goto A, Li CP, Ota S, Niki T, Ohtsuki Y,
Kitajima S, Yonezawa S, Koriyama C, Akiba S,
Hyperbilirubinemia after hematopoietic stem cell
Uchima H, Lin YM, Yeh KT, Koh JS, Kim CW,
transplantation: comparison of clinical and
pathologic findings in 41 autopsied cases. Clin
papillomavirus infection in lung and esophageal
cancers: analysis of 485 Asian cases. J Med Virol.
(12) Kozu Y, Tsuta K, Kohno T, Sekine I, Yoshida A,
Watanabe S, Tamura T, Yokota J, Suzuki K,
(4) Guan B, Mao TL, Panuganti PK, Kuhn E, Kurman
Asamura H, Furuta K, Tsuda H. The usefulness
of mutation-specific antibodies in detecting
Nakajima J, Maeda E, Fukayama M. Multicystic
epidermal growth factor receptor mutations and in
mesothelioma of the pericardium. Pathol Int.
predicting response to tyrosine kinase inhibitor
therapy in lung adenocarcinoma. Lung Cancer.
(21) Nagae G, Isagawa T, Shiraki N, Fujita T,
Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S,
(13) Kubota D, Orita H, Yoshida A, Gotoh M, Kanda
T, Tsuda H, Hasegawa T, Katai H, Shimada Y,
Soejima H, Fukayama M, Suemori H, Nakatsuji N,
prognostic biomarker for gastrointestinal stromal
demethylation in CpG-poor promoters during
tumor: validation study in multiple clinical
cellular differentiation. Hum Mol Genet. 2011;
facilities. Jpn J Clin Oncol. 2011; 41(10):
(22) Nishiyama T, Kii I, Kashima TG, Kikuchi Y,
(14) Kunita A, Kashima TG, Ohazama A, Grigoriadis
Ohazama A, Shimazaki M, Fukayama M, Kudo A.
AE, Fukayama M. Podoplanin is regulated by
Delayed re-epithelialization in periostin-deficient
AP-1 and promotes platelet aggregation and cell
mice during cutaneous wound healing. PLoS One.
migration in osteosarcoma. Am J Pathol. 2011;
(23) Ogura K, Hosono A, Yoshida A, Beppu Y, Kawai
(15) Maeda D, Shibahara J, Sakuma T, Isobe M,
lymphadenopathy, and pulmonary nodules in a
pregnant woman. Skeletal Radiol. 2011; 40(5):
!-catenin (CTNNB1) S33C mutation in ovarian
microcystic stromal tumors. Am J Surg Pathol.
(24) Shima K, Morikawa T, Yamauchi M, Kuchiba A,
Imamura Y, Liao X, Meyerhardt JA, Fuchs CS,
(16) Matsusaka K, Kaneda A, Nagae G, Ushiku T,
Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K,
tract mutations, microsatellite instability, and
Aburatani H, Fukayama M. Classification of
prognosis in 1072 colorectal cancers. PLoS One.
Epstein-Barr virus positive gastric cancers by
definition of DNA methylation Epigenotypes.
(25) Shinozaki A, Shibahara J, Noda N, Tanaka M,
Aoki T, Kokudo N, Fukayama M. Claudin-18 in
(17) Mimae T, Tsuta K, Takahashi F, Yoshida A,
biliary neoplasms. Its significance in the
Kondo T, Murakami Y, Okada M, Takeuchi M,
classification of intrahepatic cholangiocarcinoma.
Asamura H, Tsuda H. Steroid receptor expression
in thymomas and thymic carcinomas. Cancer.
(26) Shoji K. Oda K. Nakagawa S. Kawana K. Yasugi
T. Ikeda Y. Takazawa Y. Kozuma S. Taketani Y.
(18) Miyazaki H, Goto A, Hino R, Ota S, Okudaira R,
Aromatase inhibitor anastrozole as a second-line
Murakawa T, Nakajima J, Fukayama M. Pleural
hormonal treatment to a recurrent low-grade
cavity angiosarcoma arising in chronic expanding
endometrial stromal sarcoma: a case report. Med
hematoma after pneumonectomy. Hum Pathol.
(27) Sugaya M. Fujita H. Izutsu K. Oshima K.
Takazawa Y. Ohmatsu H. Yoshimi A. Takahashi
Meyerhardt JA, Shima K, Nosho K, Chan AT,
T. Kanda Y. Kurokawa M. Tamaki K. Sato S.
Giovannucci E, Fuchs CS, Ogino S. Association
Primary cutaneous anaplastic large cell lymphoma
of CTNNB1 (beta-catenin) alterations, body mass
with leg involvement: a case report and review of
index, and physical activity with survival in
11 cases. J Dermatol 2011; 38(10):1009-12.
patients with colorectal cancer. JAMA. 2011;
(28) Suehara Y, Tochigi N, Kubota D, Kikuta K,
Nakayama R, Seki K, Yoshida A, Ichikawa H,
(20) Morita S, Goto A, Sakatani T, Ota S, Murakawa T,
Hasegawa T, Kaneko K, Chuman H, Beppu Y,
prognostic biomarker candidate of synovial
antibody-dependent cellular cytotoxicity through
sarcoma revealed by proteomics. J Proteomics.
killer cell lectin-like receptor G1 on natural killer
cells. Int J Cancer. 2011; 128(9): 2125-37.
(29) Tanaka M, Shibahara J, Fukushima N, Shinozaki
(36) Yamashiki N, Sugawara Y, Tamura S, Kaneko J,
A, Umeda M, Ishikawa S, Kokudo N, Fukayama
Yoshida H, Aoki T, Hasegawa K, Akahane M,
M. Claudin-18 is an early-stage marker of
Ohtomo K, Fukayama M, Koike K, Kokudo N.
pancreatic carcinogenesis. J Histochem Cytochem.
Diagnostic accuracy of "-fetoprotein and
des-#-carboxy prothrombin in screening for
(30) Tsuta K, Tanabe Y, Yoshida A, Takahashi F,
hepatocellular carcinoma in liver transplant
Maeshima AM, Asamura H, Tsuda H. Utility of
10 Immunohistochemical Markers Including
Novel Markers (Desmocollin-3, Glypican 3,
(37) Yamazaki S, Fujioka Y, Nakamura F, Ota S,
S100A2, S100A7, and Sox-2) for Differential
Shinozaki A, Yamamoto G, Kamikubo Y, Nannya
Diagnosis of Squamous Cell Carcinoma from
Adenocarcinoma of the Lung. J Thorac Oncol.
Composite diffuse large B-cell lymphoma and
CD20-positive peripheral T-cell lymphoma.
(31) Totoki Y, Tatsuno K, Yamamoto S, Arai Y,
Hosoda F, Ishikawa S, Tsutsumi S, Sonoda K,
(38) Yoshida A, Tsuta K, Watanabe S, Sekine I,
Totsuka H, Shirakihara T, Sakamoto H, Wang L,
Fukayama M, Tsuda H, Furuta K, Shibata T.
Ojima H, Shimada K, Kosuge T, Okusaka T, Kato
Frequent ALK rearrangement and TTF-1/p63
K, Kusuda J, Yoshida T, Aburatani H, Shibata T.
co-expression of lung adenocarcinoma with
signet-ring cell component. Lung Cancer. 2011;
hepatocellular carcinoma genome. Nat Genet.
(39) Yoshida A, Tsuta K, Nakamura H, Kohno T,
(32) Ushiku T, Matsusaka K, Iwasaki Y, Tateishi Y,
Tkahashi F, Asamura H, Sekine I, Fukayama M,
Shibata T, Furuta K, Tsuda H. Comprehensive
carcinoma with invasive micropapillary pattern
histologic analysis of ALK-rearranged lung
and its association with lymph node metastasis.
carcinomas. Am J Surg Pathol. 2011; 35(8):
(33) Hanamura K, Tojo A, Kinugasa S, Asaba K,
(40) Yoshida A, Tsuta K, Nitta H, Hatanaka Y,
Onozato ML, Uozaki H, Fukayama M, Fujita T:
Asamura H, Sekine I, Grogan TM, Fukayama M,
Detection of myeloperoxidase in membranous
nephropathy-like deposits in patients with
Bright-field dual-color chromogenic in situ
anti-neutrophil cytoplasmic antibody-associated
microtubule -associated protein-like 4-anaplastic
lymphoma kinase-positive lung adenocarcinomas.
(34) Watanabe A, Ogiwara H, Ehata S, Mukasa A,
Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T,
(41) Yoshida Y, Inoh S, Murakawa T, Ota S,
Yamada Y, Fukayama M, Saito N, Miyazono K,
localization of small peripheral pulmonary
DACH1 regulates tumor-initiating activity of
nodules by percutaneous marking under computed
glioma cells. Proc Natl Acad Sci U S A. 2011;
tomography guidance. Interact Cardiovasc Thorac
(35) Yamauchi C, Fujii S, Kimura T, Kuwata T, Wada
N, Mukai H, Matsumoto N, Fukayama M, Ochiai A. E-cadherin expression on human carcinoma
No major problems, with only one blocked main in Gorge Rd attended. No new connections made. The waste water treatment plant came through the recent poor weather in reasonably good shape. Positive Dissolved Oxygen levels were maintained and instances of malodorous emissions eliminated. Tri-monthly tests required to be carried out by E-Can as a consent monitoring exercise were successfully compl