--------------------------------------------------------Pubblicazioni dottorandi cicli XXI-XXIV
XXI CICLO
ROSARIA ARNONE Savini I, Arnone R, Catani MV, Avigliano L. Origanum vulgare induces apoptosis in human colon cancer caco2 cells. Nutr Cancer. 2009;61(3):381-9. Savini I., Catani M.V., Arnone R., Rossi A., Frega G., Del Principe D., Avigliano L. Translational control of the ascorbic acid transporter svct2 in human platelets. Free Radical Biology & medicine 42 (2007) 608-616. XXII CICLO EFREM BERTINI Didona B, Codispoti A, Bertini E, Rizzo WB, Carney G, Zambruno G, Dionisi-Vici C, Paradisi M, Pedicelli C, Melino G, Terrinoni A. Novel and recurrent ALDH3A2 mutations in Italian patients with Sjogren-Larsson syndrome. J Hum Genet. 2007 Sep 28 [Epub ahead of print]. Bertini E, Oka T, Sudol M, Strano S, Blandino G. YAP: at the crossroad between transformation and tumor suppression. Cell Cycle. 2009 Jan 1;8(1):49-57. Epub 2009 Jan 24. Review. CHIARADE SIMONE Oddi S, Fezza F, Pasquariello N, D'Agostino A, Catanzaro G, De Simone C, Rapino C, Finazzi-Agro’ A, Maccarrone M. Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins. Chem Biol. 2009 Jun 26;16(6):624-32. Epub 2009 May 29 Fezza F, De Simone C, Amadio D, Maccarrone M. Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System, Subcell Biochem. 2008; 49:101-132.
Fezza F, Oddi S, Di Tommaso M, De Simone C, Rapino C, Pasquariello N, Dainese E, Finazzi-Agrò A, Maccarrone M. Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation, J Lipid Res. 2008 Jun; 49 :1216-23.
Oddi S, Fezza F, Pasquariello N, De Simone C, Rapino C, Dainese E, Finazzi-Agrò A, Maccarrone M. Evidence for the intracellular accumulation of anandamide in adiposomes, Cell Mol Life Sci. 2008 Mar; 65 : 840-50.
Bari M,, Oddi S., De Simone C., Spagnolo P., Gasperi V, Battista N., Centonze D. and Maccarrone M. Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells. Neuropharmacology 2008 Jan; 54 : 45-50 [Epub ahead of print Jul 20]. Nucci C., Gasperi V., Tartaglione R., Cerulli A., Terrinoni A., Bari M,, DeSimone C., Finazzi Agro` A., Morrone L. A., Corasaniti M. T., Bagetta G. and Maccarrone M.
--------------------------------------------------------Pubblicazioni dottorandi cicli XXI-XXIV
Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure–Induced Ischemia in Rats, Invest Ophthalmol Vis Sci. 2007 Jul;48(7):2997- 3004. ALESSANDRO GIAMBOI MIRAGLIA
Giamboi-Miraglia, A., Travagliane, S., Meschini, S., Falzano, L., Matarrese, P., Quaranta, MG., Viora, M., Fiorentini, C., and Fabbri A. Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2. Mol. Biol. Cell 2007 18: 2735-2744. Candi, E., Rufini, A., Terrinoni, A., Giamboi-Miraglia, A., Lena, AM., Mantovani, R., Knight, R., and Melino, G. DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc. Natl. Acad. Sci. 2007 104: 11999-112004. Giamboi-Miraglia, A., Travagliane, S., Filippini, P., Fabbri, A., Fiorentini, C., and Falzano L. A multinucleating Escherichia coli cytotoxic perturbs cell cycle in cultured epithelial cells. Toxicol. In Vitro 2007 21: 235-239. Falzano, L., Filippini, P., Travagliane, S., Giamboi-Miraglia, A. Fabbri, A., and Fiorentini, C. Escherichia coli cytotoxic necrotizing factor 1 blocks cell cycle G /M transition in
uroepithelial cells. Infect. Immun. 2006 74: 3765-3772. GIOVANNI PETRELLA Ascenzi P, Petrella G, Coletta M. Ferricyanide-mediated oxidation of ferrous nitrosylated sperm whale myoglobin involves the formation of the ferric nitrosylated intermediate. Biochem Biophys Res Commun. 2007 Aug 10;359(4):871-6. Epub 2007 Jun 6. De Sanctis G, Petrella G, Ciaccio C, Feis A, Smulevich G, Coletta M. A comparative study on axial coordination and ligand binding in ferric mini myoglobin and horse heart myoglobin. Biophys J. 2007 Sep 15;93(6):2135-42. PIA RIVETTI
Rivetti di Val Cervo P, Tucci P, Majid A, Lena MA, Agostini M, Bernardini S, Candi E, Cohen G, Nicotera P, Dyer MJ, Melino G. p73, miR106b, miR34a and Itch in chronic lymphocytic leucemia. Blood. 2009 Jun 18;113(25):6498-9; author reply 6499-500. Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight RA, Melino G, Candi E. mir-203 represses “stemness” by repressing DeltaNp63. Cell Death Differ. 2008 Jul;15(7):1187-95. Epub 2008 May 16. Candi E, Cipollone R, Rivetti di Val Cervo P, Gonfloni S, Melino G, Knight R. p63 in epithelial development. Cell Mol Life Sci. 2008 Oct;65(20):3126-33. Review.
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Trandafir F, Hoogewijs D, Altieri F, Rivetti di Val Cervo P, Ramser K, Van Doorslaer S, Vanfleteren JR, Moens L, Dewilde S. (2007) Neuroglobin and cytoglobin as potential enzyme or substrate. Gene, 398(1-2): 103-113. RENATO SABELLI Sabelli R, Iorio E, De Martino A, Podo F, Ricci A, Viticchiè G, Rotilio G, Paci M, Melino S. Rhodanese-thioredoxin system and allyl sulfur compounds. Implications in apoptosis induction. FEBS J. 2008 Aug; 275(15):3884-99. Epub 2008 Jul 4. XXIII CICLO
GIUSEPPE ASTARITA
Astarita G, Ahmed F, Piomelli D. Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry. Methods Mol Biol. 2009;579:201-19. Astarita G, Geaga J, Ahmed F, Piomelli D. Targeted lipidomics as a tool to investigate endocannabinoid function. Int Rev Neurobiol. Elsevier Science 2009;85:35-55. Nakahata Y, Sahar S, Astarita G, Kaluzova M, and Sassone-Corsi P. Circadian Control of the NAD+ Salvage Pathway. Science. 2009 May 1;324(5927):654-7. Epub 2009 Mar 12. Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, and Piomelli D. The fat-induced satiety factor OEA enhances memory consolidation. Proc Natl Acad Sci USA. 2009 May 12;106(19):8027-31. Epub 2009 Apr 27. Guijarro A, Fu J, Astarita G, Piomelli D. CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice. Pharmacol Res. 2009 Sep 21. [Epub ahead of print]. Astarita G, Piomelli D. Lipidomic analysis of endocannabinoid metabolism in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 14. [Epub ahead of print] Astarita G, Ahmed F, Piomelli D. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. J Lipid Res. 2008 Jan;49(1):48-57. Epub 2007 Oct 23. Potvin S, Kouassi E, Lipp O, Bouchard RH, Roy MA, Demers MF, Gendron A, Astarita G, Piomelli D, Stip E. Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. J Psychopharmacol. 2008 May;22(3):262-9. Fu J, Kim J, Oveisi F, Astarita G, Piomelli D. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R45-50. Epub 2008
--------------------------------------------------------Pubblicazioni dottorandi cicli XXI-XXIV
Apr 23. Moise AM, Eisenstein SA, Astarita G, Piomelli D, Hohmann AG. An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology (Berl). 2008 Oct;200(3):333-46. Epub 2008 Jun 11. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008 Oct;8(4):281-8. Piomelli D, Astarita G, Rapaka R. A neuroscientist's guide to lipidomics. Nat Rev Neurosci. 2007 Oct;8(10):743-54. Review. Jung KM, Astarita G, Zhu C, Wallace M, Mackie K, Piomelli D. A key role for diacylglycerol
endocannabinoid mobilization. Mol Pharmacol. 2007 Sep;72(3):612-21. Epub 2007 Jun 21. Tarzia G, Antonietti F, Duranti A, Tontini A, Mor M, Rivara S, Traldi P, Astarita G, King A, Clapper JR, Piomelli D. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007 Sep;97(9):887-94. King AR, Duranti A, Tontini A, Rivara S, Rosengarth A, Clapper JR, Astarita G, Geaga JA, Luecke H, Mor M, Tarzia G, Piomelli D. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65. ANTONELLA BIONDO
Dharmapuri S., Aurisicchio L., Biondo A., Welsh N., Ciliberto G., La Monica N. Anti- apoptotic siRNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model. Hum. Gene Ther. 2009 Feb 17. Aurisicchio L., Peruzzi D., Conforti A., Dharmapuri S., Biondo A., Giampaoli S., Fridman A., Bagchi A., Winkelmann C.T., Gibson R., Kandimalla E.R., Agrawal S., Ciliberto G., La Monica N. Treatment of Mammary Carcinomas in HER-2 Transgenic Mice through Combination of Genetic Vaccine and an Agonist of Toll-Like Receptor 9.Clin Cancer Res. 2009 Mar; 15(5):1575-84. Conforti A., Peruzzi D., La Monica N., Ciliberto G., Biondo A., Giannetti P.,Aurisicchio L. A novel model for evaluation and prediction of HLA-A2-restricted CEA cancer vaccine responses. Journal of Immunotherapy, 2009 Sept; 32(7):744-54. ELENA CAMPIONE
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Caruso R, Botti E, Sarra M, Esposito M, Stolfi C, Diluvio L, Giustizieri ML,Pacciani V, Mazzotta A, Campione E, Macdonald TT, Chimenti S, Pallone F, Costanzo A, Monteleone G. Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med. 2009 Sep;15(9):1013-5. Epub 2009 Aug 16. Ambrogi V, Campione E, Mineo D, Paternò EJ, Pompeo E, Mineo TC. Bilateral thoracoscopic T2 to T3 sympathectomy versus botulinum injection in palmar hyperhidrosis. Ann Thorac Surg. 2009 Jul;88(1):238-45. Campione E, Mazzotta A, Paternò EJ, Diluvio L, Prinz JC, Chimenti S. Effect of calcipotriol on etanercept partial responder psoriasis vulgaris and psoriatic arthritis patients. Acta Derm Venereol. 2009;89(3):288-91. Orlandi A, Costantini S Campione E, Ferlosio A, Amantea A, Bianchi L, Chimenti S, Spagnoli LG. Relation between animal-type melanoma and reduced nuclear expression of glutathione S-transferase pi. Arch Dermatol. 2009 Jan;145(1):55-62. Codispoti A, Colombo E, Zocchi L, Serra V, Pertusi G, Leigheb G, Tiberio R, Bornacina G, Zuccoli R, Ramponi A, Campione E Melino G, Terrinoni A. Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. Eur J Dermatol. 2009 Mar-Apr;19(2):114-8. Epub 2008 Dec 23. Diluvio L, Campione E, Paternò EJ, Orlandi A, Terrinoni A, Chimenti S. Peculiar clinical and dermoscopic remission pattern following imiquimod therapy of basal cell carcinoma in seborrhoeic areas of the face. J Dermatolog Treat. 2009;20(2):124-9. Campione E, Paternò EJ, Diluvio L, Orlandi A, Bianchi L, Chimenti S. Localized morphea treated with imiquimod 5% and dermoscopic assessment of effectiveness. J Dermatolog Treat. 2009;20(1):10-3. Paternò EJ, Campione E, Diluvio L, Orlandi A, Chimenti S. Imiquimod for restoring local immunity in a renal transplant patient with persistent keratoacanthoma. Dermatol Online J. 2008 Mar 15;14(3):8. Diluvio L, Campione E, Paterno EJ, Hagman JH, Anemona L, Orlandi A, Chimenti S. Acute onset disseminated superficial porokeratosis heralding diffuse large B-cell lymphoma. Eur J Dermatol. 2008 May-Jun;18(3):349-50. Epub 2008 May 13. Campione E, Paternò EJ, Diluvio L, Bianchi L, Giorgetti G, Chimenti S. Combination of low-dosage cyclosporine and topical pimecrolimus in severe atopic dermatitis with chronic hepatitis B. Acta Derm Venereol. 2008;88(1):74-5. ILDA D’ANNESSA
D'Annessa I., Chillemi G, Desideri A. Structural-dynamical properties of the Deinococcus radiodurans topoisomerase IB in absence of DNA: correlation with the human enzyme. J. Biomol. Struct. Dyn. 2009 Dec;27(3):307-18.
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Fiorani P, Tesauro C, Mancini G, Chillemi G, D'Annessa I., Graziani G, Tentori L, Muzi A, Desideri A. Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Nucleic Acids Res. 2009 Sep 18. [Epub ahead of print] Falconi M., Chillemi G., Di Marino D., D'Annessa I., Morozzo della Rocca B., Palmieri L., Desideri A. Structural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studies. Proteins 2006. 65(3): 681-91.
Chillemi G., Fiorani P., Bruselles A., Castelli S., Campagna A., Sarra O., Tesauro C., Fiorentini M., Vassallo O., D'Annessa I., Santoleri S., Desideri A. Role of flexibility and long range communication on the function of human topoisomerase I. Ital J Biochem. 2007 56(2): 110-4. Review. Losasso C, Cretaio E, Fiorani P, D'Annessa I, Chillemi G, Benedetti P. A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Res. 2008 Oct;36(17):5635-44. Chillemi G, D'Annessa I, Fiorani P, Losasso C, Benedetti P, Desideri A. Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. Nucleic Acids Res. 2008 Oct;36(17):5645-51. ANTONELLA DE COLA
Bongiorno-Borbone L, De Cola A, Vernole P, Finos L, Barcaroli D, Knight RA, Melino G, De Laurenzi V. FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. Cell Cycle. 2008 Aug;7(15):2357-67. Epub 2008 May 21. De Cola A, Bongiorno-Borbone L, Barcaroli D, Knight RA, Di Ilio C, Melino G and De Laurenzi V. FLASH degradation in response to UV-C results in Histone Locus Bodies disruption and cell cycle arrest. Oncogene. 2009 In Press RIDVAN NEPRAVISHTA
Melino S, Nepravishta R, Bellomaria A, Di Marco S, Paci M. Nucleic acid binding of the RTN1-C C-terminal region: toward the functional role of a reticulon protein. Biochemistry. 2009 Jan 20;48(2):242-53. ANTONELLA PATRIARCA
Patriarca A, Eliseo T, Sinibaldi F, Piro MC, Melis R, Paci M, Cicero DO, Polticelli F, Santucci R, Fiorucci L. ATP acts as a regulatory effector in modulating structural transitions of cytochrome c: implications for apoptotic activity. Biochemistry. 2009 Apr 21;48(15):3279-87. Sinibaldi F., Fiorucci L.,Patriarca A., Laceri R., Ferri T., Coletta M., and Santucci R.
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Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength, Biochemestry 2008 47, 6928-6935. DIEGO SBARDELLA
Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M. The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. J Mol Biol. 2009 Feb 20;386(2):419-34. Epub 2008 Dec 14. VALERIA SERRA
Codispoti A, Colombo E, Zocchi L, Serra V, Pertusi G, Leigheb G, Tiberio R, Bornacina G, Zuccoli R, Ramponi A, Campione E, Melino G, Terrinoni A. Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. Eur J Dermatol. 2009 Mar-Apr;19(2):114-8. Epub 2008 Dec 23. PubMed PMID: 19106041. GRAZIA RAFFAELLA TUNDO
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M. Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity. J Mol Biol. 2009 Feb 6;385(5):1556-67. Epub 2008 Nov 25. XXIV CICLO
ALESSIA BELLOMARIA
Melino S, Nepravishta R, Bellomaria A, Di Marco S, Paci M. Nucleic acid binding of the RTN1-C C-terminal region: toward the functional role of a reticulon protein. Biochemistry. 2009 Jan 20;48(2):242-53. RAFFAELE FABRINI
Fabrini R, De Luca A, Stella L, Mei G, Orioni B, Ciccone S, Federici G, Lo Bello M, Ricci G. Monomer-Dimer Equilibrium in Glutathione Transferases: A Critical Re- Examination. Biochemistry. 2009 Nov 3;48(43):10473-10482. Liebau E, Dawood KF, Fabrini R, Fischer-Riepe L, Perbandt M, Stella L, Pedersen JZ, Bocedi A, Petrarca P, Federici G, Ricci G. Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119. J Biol Chem. 2009 Aug 14;284(33):22133-9. Epub 2009 Jun 16.
Great Companions LEARN TO BE YOUR DOG’S REWARD J u l y , 2 0 1 1 V o l u m e 2 , I s s u e 3 Great Companions Rally Trial Are you ready for the next Great Companions APDT Rally Trial? On September 24th and 25th, Great Companions will be holding our fall APDT Rally trial. Trialing at Great Companions is always fun, but this year, exhibitors can spend the
Les embarras du lieutenant Passepoil Ce matin, le commissaire divisionnaire Fabien du commissariat central de Quimper fut surpris par un évènement inédit : le lieutenant Albert Passepoil, d’ordinaire totalement effacé, lui demandait audience ! Comme le lieutenant s’était distingué maintes fois par sa maîtrise d’Internet qui avait grandement simplifié les actions de ses collè