J Clin Periodontol 2002; 29: 211–215Copyright C Munksgaard 2002Printed in Denmark . All rights reservedFrank Schwarz1, Nicole Arweiler2, Thomas Georg3 and Elmar Reich2
Desensitizing effects of an Er:YAG 1DepartmentofOralandMaxillofacial
Surgery, Ludwig Maximilians University,Munich, Germany; 2Department of
Periodontology and Conservative Dentistry,University of Saarland, Homburg, Germany;3Institute of Medical Biometrics, Epidemiology
and Medical Informatics, University ofSaarland, Homburg, Germany
Schwarz F, Arweiler N, Georg T, Reich E: Desensitizing effects of anEr:YAG laser on hypersensitive dentine. A controlled, prospective clinical study. J Clin Periodontol 2002; 29: 211–215. C Munksgaard, 2002. Abstract Aim: The aim of the present study was to evaluate and compare the desensitizing effects of an Er:YAG laser (KEY IIA, KaVo, Germany) and Dentin ProtectorA (Vivadent, Germany) on cervically exposed hypersensitive dentine. Method: A group of 30 patients showing a total of 104 contralateral pairs of hypersensitive and caries-free teeth was selected and randomly allocated in a split- mouth design to either (1) Er:YAG laser (80 mJ/pulse, 3 Hz), or (2) the appli- cation of Dentin ProtectorA (polyurethane-isocyanate 22.5%; methylenechloride 77.5%) whereat one pair served as an untreated control in each patient. The degree of sensitivity to a thermal stimulus was determined qualitatively with an evaporative stimulus defined as a 3-s air blast at a distance of 2 mm from each site to be tested. A qualitative registration of the degree of discomfort was determined according to an arbitrary pain scale in 4 degrees. Recordings were assessed before treatment, immediately after, 1 week, 2 and 6 months after treat- ment by 1 blinded examiner. Results: Both treatment forms resulted in significant improvements of discomfort immediately after and 1 week post treatment. After 2 months, the discomfort in the Dentin ProtectorA group increased up to 65% of the baseline score and even up to 90% after 6 months, whereas the effect of the laser remained at the same level that was achieved immediately after treatment. The differences im- mediately after, 1 week, 2 and 6 months post treatment between both groups were statistically high significant (pр0.001; respectively). Compared to the untreated control group, both treatment forms resulted in a significant reduction of dis-
comfort at each follow-up examination.
laser; dentine hypersensitivity; polyurethane-
Conclusion: It was concluded that desensitizing of hypersensitive dentine with an
Er:YAG laser is effective and the maintenance of the positive result was moreprolonged than with Dentin ProtectorA.
theory’’, movements of fluid within ex-
Flynn et al. 1985, Scherman & Jacobs-
sodium fluoride, are also effective (Ged-
en 1992). So far, there is relatively little
or solution resulted in positive desensit-
1990). According to the ‘‘hydrodynamic
various laser systems are discussed for a
ide) lasers are limited due to their ther-
tivity treatment whilst on the trial.
ness & Löe 1964) was recorded on the
Study design
an untreated control in each patient. Treatments
and even 20,000 ¿ greater than the
and left sides. All patients were treated
rectly result in a decrease of dentine hy-
persensitivity. In this context, the appli-
pulse, and a repetition rate of 3 Hz with
Oral hygiene
structions given by the manufacturer.
ficial layers of the dentinal fluid. How-
tern. All contralateral teeth received an
Clinical measurements
hypersensitive teeth served as a control.
The degree of sensitivity to a evaporative
Material and Methods
onds cold air blast (temperature range of
Subject selection
19–20 æC) at a distance of 2 mm from the
site to be tested. Sensitivity was assessed
four degrees (Table 1). During testing the
Statistical analysis
clinical parameters were calculated. Table 1. Pain scale to assess the degree of
surfaces. Criteria for exclusion from the
ing to the distribution of the data, non-
study were: (a) carious lesions on the se-
lected or neighbouring teeth, (b) any de-
and parametric tests (Student paired t-
sensitizing therapy on the selected teeth
during the last 6 months, (c) cervical fill-
ings on the selected teeth. Other reasons
of pр0.05 were accepted as statistically
for exclusion were a history of allergy to
Desensitizing effects of an Er:YAG laserTable 2. Mean degree of discomfort and standard deviation in all groups over 6 months (nΩ
ductions of discomfort were unalteredeven 6 months following the initial
The stars indicate statistically significant differences between groups (Wilcoxon signed ranks
test) (n.s. pу0.05, * pр0.05, ** pр0.01, *** pр0.001).
tine hypersensitivity, whereas the use oflasers has often been propagated for thisindication. In previous clinical studies it
Table 3. Mean gingival recessions (∫SD) in all groups over 6 months (nΩ30 patients)
has been demonstrated that the pulsedNd:YAG laser is also an effective tool in
reducing dentine hypersensitivity to cold
air stimuli. It produced an immediate ef-
Harper & Midda 1992, Gelskey et al.
1993, Gutknecht et al. 1997). It was pre-sumed that dentine may be fused during
The stars indicate statistically significant differences between groups (paired t-test) (n.s. pу0.05, * pр0.05, ** pр0.01, *** pр0.001).
Harper & Midda 1992, Gelskey et al. 1993). Similar results have also beenfound with the CO2 laser (Moritz et al. Table 4. Mean plaque index (∫SD) in all groups over 6 months (nΩ30 patients)
1996). Its effectiveness is probably due to
ments of fluid in the tubules, fusing the
elimination of dentine hypersensitivity.
In this context it is important to mention
The stars indicate statistically significant differences between groups (paired t-test) (n.s. pу0.05, * pр0.05, ** pр0.01, *** pр0.001).
tubular diameters that are significantlywider (2¿) than those of non-sensitiveteeth, so it would appear that treatment
detrimental pulpal effects or allergic re-
focused at decreasing the radius is a pre-
tings of 80 mJ/pulse at 3 Hz, used in the
present study, are lower than the ablation
groups (pу0.05; respectively) (Table 3).
in all groups with progressive reductions
(pу0.05; respectively) (Table 4).
insoluble salts in the exposed tubules are
responsible for an obturation of the den-
Discussion
after, 1 week, 2 and 6 months post treat-
The results of the present clinical trial
tivity of teeth. The pain threshold of the
cally high significant (pр0.01; respec-
nerve fibers seems to be lowered in pres-
son & Brannström 1974, Olgart et al.
comfort throughout the study period.
1974). In this context it is important to
torA. The results especially illustrate ef-
frei waren ausgewa¨hlt und nach einem Zu-
d’incomfort a e´te´ de´termine´ suivant une
fallsprinzip einem Splitmouth-Design zuge-
e´chelle de douleur arbitraire de 4 degre´s. Les
(Ando et al. 1996, Hibst et al. 1996).
enregistrements ont e´te´ effectue´s avant le
traitement, imme´diatement apre`s ainsi qu’u-
Dentin ProtectorA (Polyurethan-Isocyanate
ne semaine, 2 et 6 mois apre`s le traitement
und ein Paar bei jedem Patienten diente als
Re´sultats: Les deux types de traitement se
sont accompagne´s d’une diminutionde l’in-
keitsgrad bezu¨glich eines thermischen Stimu-
confort imme´diatement apre`s et 1 semaine
ate, as the active substance, has not yet
lus wurde qualitativ bestimmt, indem jede
apre`s le traitement. Apre`s 2 mois, l’inconfort
Stelle aus 2 mm Entfernung mit einem Luft-
dans le groupe Dentin ProtecorA atteignait
ably lead to the creation of a peripheral
bla¨ser fu¨r 3 Sekunden getrocknet wurde. Ent-
65% du score initial et meˆme 90% apre`s 6
intrinsic barrier within the lumen of the
sprechend einer Schmerzskala mit Einteilung
mois tandis que l’effet obtenu par le laser de-
dentinal tubules. In this context the re-
nach vier Graden wurde eine qualitative Be-
meurait au meˆme niveau que celui atteint jus-
urteilung des Grades der Beeintra¨chtigung
te apre`s le traitement. Les diffe´rences imme´-
diates, 1 semaine, 2 et 6 mois apre`s le traite-
Behandlung, direkt anschließend, sowie eine
ment entre les deux groupes e´taient tre`s
significatives (pр0.001). Compare´es au grou-
handlung durch einen bezu¨glich der Therapie
pe controˆle non-traite´, les deux traitements
able for the penetration of the resin-ad-
re´sultaient en une re´duction significative de
Ergebnisse: Direkt nach der Behandlung und
l’inconfort lors de chaque examen. Conclusion: La de´sensibilisation dentinaire
lungsarten eine signifikante Verbesserung der
avec le laser Er:YAG est efficace et le main-
Beeintra¨chtigung zur Folge. Nach zwei Mo-
tien de son re´sultat positif plus prolonge´
naten erho¨hte sich in der Dentin ProtextorA-
Gruppe die Beeintra¨chtigung auf Werte bis
removal of this peripheral intrinsic bar-
zu 65% der Ausgangswerte und sogar auf bis
References
Wirkung des Lasers auf dem gleichen Niveau
Addy, M. (1990) Etiology and clinical impli-
wie direkt nach der Behandlung blieb. Die
cations of dentine hypersensitivity. DentalClinics of North America 34, 503–514.
Addy, M. & Dowell, P. (1983) Dentine hyper-
control (Addy & Dowell 1983). This phe-
sensitivity – a review. Clinical and in vitro
hoch signifikant (pр0.001). Beide Behand-
evaluation of treatment agents. Journal of
lungsarten hatten im Vergleich zur unbehan-
Clinical Periodontology 10, 351–363.
delten Kontrollgruppe bei jeder Nachunter-
Ando, Y., Aoki, A., Watanabe, H. & Ishika-
suchung eine signifikante Reduktion der Be-
wa, I. (1996) Bactericidal effect of the Er:-
YAG laser on periodontopathic bacteria. Schlussfolgerung: Es wurde die Schlussfolge- Lasers in Surgery and Medicine 19, 190–
rung gezogen, dass die Desensibilisierung
Aoki, A., Ando, A., Watanabe, H. & Ishika-
Er:YAG-Laser effektiv ist und die Aufrecht-
wa, I. (1996) I. In vitro studies on laser
erhaltung der positiven Ergebnisse la¨nger an-
Er:YAG laser. Journal of Periodontology 65, 1097–1106.
Blitzer, B. (1967) A consideration of the
ity, especially while the 6 months results
Re´sume´
possible causes of dentine hypersensitivity. Effet de de´sensibilisation de dents hypersensi-
Treatment by strontium-ion dentifrice. bles par le laser Er:YAG. Une e´tude cliniquePeriodontics 5, 318–321.
the obtained positive results. Especially
But: Le but de cette e´tude a e´te´ d’e´valuer et
de comparer les effets de´sensibilistateurs
d’un laser Er:YAG (KEY IIA, KaVo, Alle-
Sensory mechanism in dentine. Anderson,
magne) et du Dentin ProtectorA (Vivadent,
D. J. ed., pp. 73–79. Oxford: Pergamon.
Allemagne) sur la dentine hypersensible ex-
Brannström, M., Linden, L. A. & Aström,
Zusammenfassung Methode: Un groupe de 30 patients avec 104
and pulp fluid: its significance in relation
paires contralate´rales de dents hypersensibles
to dental pain. Caries Research 1, 310. Desensibilisierungswirkung des Er:YAG-La-
non-carie´es a e´te´ se´lectionne´ et e´tudie´ selon
Dowell, P. & Addy, M. (1983) Dentine-hyper-
sers auf u¨berempfindliches Dentin. Eine kon-
un mode`le de bouche divise´e soit (1) dans le
sensitivity – A review, etiology, symptoms
trollierte, prospektive klinische Studie
groupe Er:YAG (80 mJ/impulsion, 3 Hz), ou
and theories of pain production. JournalZiel: Das Ziel der vorliegenden Studie war es,
(2) par l’application de Dentin ProtecorA
of Clinical Periodontology 10, 341–350.
die Desensibilisierungswirkung eines Er:Y-
(isocyanate polyure´thane 22.5%; chlorure de
Dowell, P., Addy, M. & Dummer, P. (1985)
me´thyle`ne 77.5%), une paire servant de
Dentine hypersensitivity: Aetiology, differ-
contro¨le non-traite´ chez chaque patient. Le
ential diagnosis and management. British
degre´ de sensibilit´ a` un stimulus thermique a
Dental Journal 158, 92–96.
u¨berempfindliches Dentin zu vergleichen.
e´te´ de´termine´ qualitativement a` l’aide d’un
Flynn, J., Galloway, R. & Orchadson, R. Methode: Es wurde eine Gruppe von 30 Pati-
stimulus d’e´vaporation de´fini a` 3 s de souffle
a` une distance de 2 mm pour chaque site tes-
teeth in the west of Scotland. Journal of
Zahnpaaren, die u¨berempfindlich und karies-
te´. Un enregistrement qualitatif du degre´
Dentistry 13, 230–236. Desensitizing effects of an Er:YAG laser
Gedalia, I., Brayer, L., Kalter, N., Richter,
ionizing toothbrush in the control of den-
Scherman, A. & Jacobsen, P. L. (1992) Man-
M. & Stabholz, A. (1978) The effect of
tinal hypersensitivity. Journal of Periodon-
aging dentin hypersensitivity: what treat-
fluoride and strontium application on den-
tology 53, 353–359.
ment to recommend to patients. Journal of
tine: in vivo and in vitro studies. Journal
Midda, M. (1992) The use of lasers in peri-
American Dental Association 123, 57–61. of Periodontology 49, 269–272.
odontology. Current Opinion in Dentistry
Silness, J. & Löe, H. (1964) Periodontal dis-
Gelskey, S. C., White, J. M. & Pruthi, V. K. 2, 104–108.
Moritz, A., Gutknecht, N., Schoop, U., Wer-
laser in the treatment of dental hypersens-
nisch, J., Lampert, F. & Sperr, W. (1995)
dition. Acta Odontologica Scandinavica 22,
itivity. Scientific Journal 59, 377–386.
Effects of CO2 laser irradiation on treat-
Graf, H. & Galasse, R. (1977). Morbidity,
Takeda, F. H., Harashima, T., Kimura, Y. &
sults of an in vitro study. Journal of Clin-
hypersensitive teeth. Journal of Dentalical Laser Medicine and Surgery 13, 397– Research 56 (special issue), 162, abstr. 479.
Gutknecht, N., Moritz, A., Dercks, H. W. &
Moritz, A., Gutknecht, N., Schoop, U., Go-
of laser. International Endodontic Journal
Lampert, F. (1997) Treatment of hypersen-
harkhay, K., Ebrahim, D., Wernisch, J. &
32, 32–39.
Walsh, J. T., Flotte, T. J. & Deutsch, T. F.
parison of the use of various settings in
treated dental necks, in comparison with a
(1989) Er:YAG laser ablation of tissue: Ef-
an in vivo study. Journal of Clinical Laser
fect of pulse duration and tissue type on
Medicine & Surgery 15, 171–174.
study. Journal of Clinical Laser Medicine
thermal damage. Lasers in Surgery andand Surgery 14, 27–32. Medicine 9, 314–326.
Volpe, A. & King, W. (1972) Clinical study
Olgart, L., Brannström, M. & Johnson, G.
Walsh, J. T. & Cummings, J. P. (1994) Effect
evaluating the desensitizing effect of denti-
(1974) Invasion of bacteria into dentinal
of the dynamic optical properties of water
tubules – experiment in vivo and in vitro.
on mid-infrared laser ablation. Lasers inActa Odontologica Scandinavica 32, 61–70. Surgery and Medicine 15, 295–305.
alin. Journal of Periodontology 43, 367–
Pick, R. M., Pecaro, B. C. & Silberman, C.
White, J. M., Goodis, H. E. & Rose, C. L.
J. (1985) The laser gingivectomy: The use
(1987) Use of the pulsed Nd:YAG laser for
Hibst, R., Stock, K., Gall, R. & Keller, U.
of CO2 laser for removal of phenytoin hy-
intraoral soft tissue surgery. Lasers in
perplasia. Journal of Periodontology 56, Surgery and Medicine 7, 207–213.
ation. Lasers in Surgery and Medicine2922, 119–126.
Jensen, A. L. (1965) Hypersensitivity con-
persensitivity. British Dental Journal 172, Department of Oral and Maxillofacial
clinical investigation. Journal of the Ameri-
Rimondini, L., Baroni, C. & Carrassi, A. can Dental Association 68, 216.
Johnson, G. & Brannström, M. (1974) The
and non-sensitive dentine. Journal of Clin-
sensitivity of dentine. Changes in relation
ical Periodontology 22, 899–902.
to condition at exposed tubules aperture.
Schaeffer, M. L., Bixler, D. & YU, P.-L. Acta Odontologica Scandinavica 32, 28–29.
(1971) The effectiveness of iontophoresis
Johnson, R. H., Zulqar-Nain, B. J. & Koval,
J. J. (1982) The effectiveness of an electro-
Journal of Periodontology 42, 695.
Protocolos Dispensación activa Farmacéutica de Carbayín Alto (Asturias). REAP de quinolonas por vía oral En los últimos años, se observa una tendencia creciente dosis. Se han utilizado dosis más elevadas de 1.500 mg/día. en la demanda de quinolonas, tanto de antiguas moléculas como de nueva generación. Dentro del grupo de antibióti- • Información para la correcta a
Interactions between the ART and antidepressants Tricyclic antidepressants (TCA) possess a small therapeutic range, thus, drug concentration can quickly reach toxic levels. Among others, cardiac arrhythmia, anticholinergic effects, sedation and confusion may occur if the drug concentration is reaching toxic levels. As the HI- virus affects the basal ganglia and cause anticholinergic effec