PUBLICATIONS ON THERAPEUTICAL APPROACHES 1. Navarro J, Pizarro A, Fernández-Cruz E, Fresno M, Muñoz-Fernández MA.
“Pentoxifylline preferentially inhibits interleukin-10 production by HIV-1 infected human T cells”. AIDS 1994; 8(8):1192-4. 2. Pimentel-Muiños FX, Muñoz-Fernández MA, Fresno M. “Control of T
lymphocyte activation and interleukin-2 receptor expression by endogenously secreted lymphokines”. J Immunol 1994; 152(12):5714-22. 3. Navarro J, Punzón MC, Pizarro A, Fernández-Cruz E, Fresno M, Muñoz-
Fernández MA. “Pentoxifylline inhibits acute HIV-1 replication in human T cel s by a mechanism not involving inhibition of tumor necrosis factor synthesis or nuclear factor kappa-β activation”. AIDS 1996; 10(5):469-75. 4. Muñoz-Fernández MA, Navarro J, García A, Punzón C, Fernández-Cruz E,
Fresno M. “Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor kappa-β activation”. J Allergy Clin Immunol 1997; 100:838-45. 5. San José E, Muñoz-Fernández MA, Alarcón B. “Megalomicin inhibits HIV-1
replication and interferes with gp160 processing”. Virology 1997; 239(2):303- 14. 6. Navarro J, Punzón C, Jiménez JL, Fernández-Cruz E, Fresno, Muñoz-
Fernández MA. “Inhibition of the phosphodiesterase type IV supresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells. Involvement of NF-Kappa B and NFAT”. J Virol 1998; 72(6):4712-20. 7. San José E, Muñoz-Fernández MA, Alarcón B. “Retroviral vector-mediated
expression in primary human T cells of an endoplasmic reticulum-retained CD4 chimera inhibits human immunodeficiency virus type-1 replication”. Hum Gene Ther. 1998; 9(9):1345-57. 8. Jiménez JL, Punzón C, Navarro J, Muñoz-Fernández MA, Fresno M.
“Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaβ and nuclear factor of activated T cells activation”. J Pharmacol Exp Ther 2001; 299(2):753-9. 9. Bermejo Martín JF, Muñoz-Fernández MA. “Severe acute respitarory
syndrome in children: A clue better understand the disease and advancing towards solutions”. Act Paediatr 2004; 93(6):856-7. 10. Bermejo JF, Muñoz-Fernández MA. “Severe acute respiratory syndrome, a
pathological immune response to the new coronavirus-implications for
11. Fernández Cruz E, Moreno S, Navarro J, Clotet B, Bouza E, Carbone J, Peña
JM, Pérez Molina J, Podzamczer D, Rubio R, Ocaña I, Pulido F, Viciana P, Maradona JA, Blazquez R, Barros C, Quereda C, Rodriguez-Sainz C, Gil J, Abad ML, Díaz L, Cantó C, Muñoz MA, Ferrer E, Jou A, Sierra G, Díaz M, López F, Gatell JM, González-Lahoz J, STIR-2102 TEAM. “Therapeutic immunization with an inactivated HIV-1 immunogen plus antiretrovirals versus antiretroviral therapy alone in asymptomatic HIV-infected subjects”. Vaccine 2004; 22(23-24):2966-73. 12. Jimenez JL, Iñiguez MA, Muñoz-Fernández MA, Fresno M. “Effect of
phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes”. Cell signal 2004; 16(12):1363-73. 13. Alcamí J, Josep Munné J, Muñoz-Fernández MA, Esteban M. “Current
situation in the development of a preventive HIV vaccine”. Enferm Infecc Microbial Clin 2005; 23(2):15-24. 14. Ortega P, Bermejo JF, Chonco L, De Jesús E, De la Mata J, Fernández G,
Flores JC, Gómez R, Serramía MJ, Muñoz-Fernández MA. “Novel water- soluble carbosilane dendrimers: synthesis and biocompatibility”. Eur J Inorg Chem 2006; 7:1388-96. 15. Bermejo JF, Ortega P, Chonco L, Eritja R, Samaniego R, Müllner M, de Jesús
E, de la Mata FJ, Flores JC, Gomez R, Muñoz-Fernández MA. “Water-soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides. An evaluation for medical applications”. Chem-Eur J 2007; 13(2):483-95. 16. Chonco L, Bermejo-Martin JF, Ortega P, Shcharbin D, Pedziwiatr E, Klajnert B,
de la Mata FJ, Eritja R, Gomez R, Bryszewska M, Muñoz-Fernandez MA. “Water-soluble carbosilane dendrimers protect phosphorothioate oligonucleotides from binding to serum proteins”. Org Biomol Chem 2007; 21;5(12):1886-93. 17. Lasso JM, Del Rio M, Garcia M, Martínez Calleja V, Nava P, Muñoz-
Fernandez MA, Pérez Cano R. “Improving flap survival by transplantation of a VEGF-secreting endothelised scaffold during distal pedicle flap creation”. J Plast Reconstr Aesthet Surg 2007; 60(3):279-86. 18. Shcharbin D, Pedziwiatr E, Chonco L, Bermejo-Martin JF, Ortega P, de la
Mata FJ, Eritja R, Gomez R, Klajnert B, Bryszewska M, Muñoz-Fernandez MA. “Analysis of interaction between dendriplexes and bovine serum albumin”. Biomacromolecules 2007, 8(7):2059-62. 19. Ortega P, Copa-Patiño JL, Muñoz-Fernandez MA, Soliveri J, Gomez R, de la
Mata FJ. “Amine and ammonium functionalization of chloromethylsilane- ended dendrimers. Antimicrobial activity studies”. Org Biomol Chem 2008; 6(18):3264-9. 20. Weber N, Ortega P, Clemente MI, Shcharbin D, Bryszewska M, de la Mata FJ,
Gómez R, Muñoz-Fernández MA. “Characterization of carbosilane dendrimers as effective carriers of siRNA to HIV-infected lymphocytes”. J Control Release 2008; 132(1):55-64. 21. Clemente MI, Alvarez S, Serramía MJ, Turriziani O, Genebat M, Leal M, Fresno
M, Muñoz-Fernández MA. “Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4”. Antivir Ther 2009; 14(8):1101-11. 22. Gras R, Almonacid L, Ortega P, Serramia MJ, Gomez R, de la Mata FJ,
Lopez-Fernandez LA, Muñoz-Fernandez MA. “Changes in gene expression pattern of human primary macrophages induced by carbosilane dendrimer 2G-NN16”. Pharm Res 2009; 26(3):577-86. 23. Ortega P, Serramia MJ, Samaniego R, de la Mata FJ, Gomez R, Muñoz-
Fernández MA. “Carbosilane dendrimers peripherally functionalized with dansyl fluorescence tags and their cellular internalization studies”. Org Biomol Chem 2009; 7, 3079-85. 24. Pedziwiatr E, Shcharbin D, Chonco L, Ortega P, de la Mata FJ, Gomez R,
Klajnert B, Bryszewska M, Muñoz-Fernández MA. “Binding properties of water- soluble carbosilane dendrimers”. J Fluoresc 2009; 19(2):267-75. 25. Posadas I, López-Hernández B, Clemente MI, Jiménez JL, Ortega P, de la
Mata J, Gómez R, Muñoz-Fernández MA, Ceña V. “Highly Efficient Transfection of Rat Cortical Neurons Using Carbosilane Dendrimers Unveils a Neuroprotective Role for HIF-1alpha in Early Chemical Hypoxia-Mediated Neurotoxicity”. Pharm Res 2009; 26(5):1181-91. 26. Rasines B, Hernández-Ros JM, de las Cuevas N, Copa-Patiño JL, Soliveri J,
Muñoz-Fernández MA, Gómez R, de la Mata FJ “Water-stable ammonium- terminated carbosilane dendrimers as efficient antibacterial agents”. Dalton Trans 2009; (40):8704-13.
PROMOTING ACCESS TO JUSTICE- ISSUES AND CHALLENGES Munmun Singh, Fourth year student of B.A. LL.B. National Law University Delhi1 Abstract: India is rightly acclaimed for achieving a flourishing constitutional order, presided over by an inventive and activist judiciary, aided by a proficient bar, supported by the state and cherished by the public. At the same time, the courts, and
Unexpected high serum levels of tacrolimus aftera single topical application in an infantResearch Institute for Environmental Health at the Heinrich-Topical tacrolimus has been found to be effective andsafe for the treatment of atopic dermatitis in adults andSupported by the Elterninitiative Kinderkrebsklinik e. V., Du¨sseldorf, andchildren.We report an infant with severe combinedDeutsche