Vele mensen zullen het gevoel wel kennen, ze zitten aan de antibiotica, maar hebben dan een feestje antibiotica en ibuprofen samen Antibiotica zijn medicijnen die alleen op recept te krijgen zijn.
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Merck Consumer Care Canada Inc. 3535 Trans-CanadaPointe Claire, QuebecCanada H9R 1B4
MATERIAL SAFETY DATA SHEET Intervet Schering-Plough Animal Health urges each user or recipient of this MSDS to read the entire data sheet to become aware of the hazardsassociated with this material.SECTION 1. IDENTIFICATION OF SUBSTANCE AND CONTACT INFORMATION MSDS NAME: Ectiban Pour-On Insecticide SYNONYM(S):
Ectiban Pour-On InsecticideAgrilab Back Side InsecticideAspen Ecto Zap InsecticideAtroban Delice Pour-On InsecticideDelice Pour-On InsecticideDurvet Ectiban Delice InsecticideUniversal-Coop InsecticidedEctiban Delice Insecticide
MSDS NUMBER: EMERGENCY NUMBER(S):
(908) 423-6000 (24/7/36) English OnlyTransportation Emergencies - CANUTEC: (613) 996-6666 (Canada)
INFORMATION:
Animal Health Technical Services:(888) 306-0069 (Canada)
MERCK MSDS HELPLINE:
(800) 770-8878 (US and Canada)(908) 473-3371 (Worldwide)Monday to Friday, 9am to 5pm (US Eastern Time)
SECTION 2. HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
LiquidClear, AmberOdorlessCombustible. May be irritating to respiratory system. May be an aspiration hazard if ingested. May be harmful by inhalation or if swallowed. May cause effects to:central nervous systemgastrointestinal tractrespiratory systemcardiovascular systemExtremely toxic to fish and aquatic organisms. POTENTIAL HEALTH EFFECTS: SECTION 2. HAZARDS IDENTIFICATION
This product is a permethrin insecticide and contains petroleum distallates. This product has been shown to be slightly irritating to the skin and eyes ofanimals. This product did not cause skin sensitization in animals.
This product contains permethrin, a synthetic Type I pyrethroid ester. Occupational exposure to permethrin has induced temporary skin and facialsensations (feelings of numbness and tingling). Workers exposed to permethrin have also reported irritative symptoms, such as itching and burning ofthe skin, itching and irritation of the eyes, and irritation of the upper respiratory tract as well as increased nasal secretions. Anaphylactic reactionsincluding bronchospasm and shock may occur in very sensitive individuals. Ingestion of large amounts may cause central nervous system effectsresulting in seizures, coma, and respiratory arrest.
Ingestion of pyrethroid esters has caused stomach pain, nausea and vomiting, headache, dizziness, numbness and tingling, anorexia, fatigue, tremors,and intermittent convulsions.
Petroleum distillates may be skin, eye, and respiratory tract irritants. Repeated skin contact may cause oil acne or dermatitis. Exposure to largeamounts of petroleum distillates by inhalation or ingestion may cause CNS depression or excitement, headaches, drowsiness, nausea, vomiting,diarrhea, laxative effects, lung damage, or an irregular heartbeat. Aspiration of liquid into the lungs may produce chemical pneumonitis. LISTED CARCINOGENS
Permethrin technical is classified by IARC as a Group 3 carcinogen (unclassifiable as to carcinogenicity in humans). SECTION 3. COMPOSITION AND INFORMATION ON INGREDIENTS PRODUCT USE: CHEMICAL FORMULA:
The formulations for these products are proprietary information. These formulations have the same hazardous profile; however, the presence ofhazardous ingredients may vary by formulation. Only hazardous ingredients in concentrations of 1% or greater and/or carcinogenic ingredients inconcentrations of 0.1% or greater are listed in the Chemical Composition table. Active ingredients in any concentration are listed. For additionalinformation about carcinogenic ingredients see Section 2. CHEMICAL COMPOSITION INGREDIENT CAS NUMBER
Distillates, petroleum, solvent-refined light paraffinic
Distillates, petroleum, solvent-refined heavy paraffinic
ADDITIONAL INFORMATION:
This MSDS is written to provide health and safety information for individuals who will be handling the finalproduct formulation during research, manufacturing, and distribution. For health and safety information forindividual ingredients used during manufacturing, refer to the appropriate MSDS for each ingredient. Referto the package insert or product label for handling guidance for the consumer. SECTION 4. FIRST AID MEASURES INHALATION:
Remove to fresh air. If any trouble breathing, get immediate medical attention. Administer artificialrespiration if breathing has ceased. If irritation or symptoms occur or persist, consult a physician. SKIN CONTACT:
In case of skin contact, while wearing protective gloves, carefully remove any contaminated clothing,including shoes, and wash skin thoroughly with soap and water. If irritation or symptoms occur or persist,consult a physician. EYE CONTACT:
In case of eye contact, immediately rinse eyes thoroughly with plenty of water. If wearing contact lenses,remove only after initial rinse, and continue rinsing eyes for at least 15 minutes. If irritation occurs orpersists, consult a physician. INGESTION:
Rinse mouth and drink a glass of water. Do not induce vomiting unless under the direction of a qualifiedmedical professional or Poison Control Center. If symptoms persist, consult a physician. NOTE TO PHYSICIAN:
Vomiting is contraindicated due to the possibility of aspiration pneumonia. MSDS NAME: Ectiban Pour-On Insecticide MSDS NUMBER: SP000936 SECTION 5. FIRE FIGHTING MEASURES FLAMMABILITY DATA:
72.2 deg C ( 162 deg F ) Method: SETA Flash
Combustible (US OSHA Criteria)Combustible (Canada WHMIS Criteria)
SPECIAL FIRE FIGHTING PROCEDURES: Wear full protective clothing and self-contained breathing apparatus (SCBA). SUITABLE EXTINGUISHING MEDIA: Carbon dioxide (CO2), extinguishing powder or water spray.
See Section 9 for Physical and Chemical Properties. SECTION 6. ACCIDENTAL RELEASE MEASURES PERSONAL PRECAUTIONS: Wear appropriate personal protective equipment as specified in Section 8. Keep personnel away from the clean-up area. SPILL RESPONSE / CLEANUP: All spills should be handled according to site requirements and based on precautions cited in the MSDS. In the case of liquids, use proper absorbent materials. For laboratories and small-scale operations, incidental spills within a hood or enclosure should be cleaned by using a HEPA filtered vacuum or wet cleaning methods as appropriate. For large dry or liquid spills or those spills outside enclosure or hood, appropriate emergency response personnel should be notified. In manufacturing and large-scale operations, HEPA vacuuming prior to wet mopping or cleaning is required. ENVIRONMENTAL PRECAUTIONS: This product is very toxic to aquatic organisms. Do not allow product to reach ground water, water course, sewage or drainage systems.
See Sections 9 and 10 for additional physical, chemical, and hazard information. SECTION 7. HANDLING AND STORAGE HANDLING: Keep containers adequately sealed during material transfer, transport, or when not in use. Wash face, hands, and any exposed skin after handling. Do not eat, drink, or smoke when using this substance or mixture.
Appropriate handling of this material is dependent on many factors, including physical form, duration and frequency of process or task, and effectivenessof engineering controls. Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all exposure controlmeasures. See Section 8 (Exposure Controls) for additional guidance. STORAGE: Keep away from heat, sparks, open flames, and direct sunlight. Store in a cool, dry, well ventilated area.
See Section 8 for exposure controls and additional safe handling information. SECTION 8. EXPOSURE CONTROLS AND PERSONAL PROTECTION S-P HEALTH HAZARD CATEGORY (HHC): The Schering-Plough Health Hazard Category (HHC) for this material is HHC3. Materials in this category are considered high health hazards. Health Hazard Categories are intended to be a component of workplace risk assessment. Consult your site safety and industrial hygiene staff for guidance on handling and control strategies. EXPOSURE CONTROLS The health hazard risks of handling this material are dependent on many factors, including physical form, duration and frequency of process or task, and effectiveness of engineering controls. Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all exposure control measures. Exposure controls for normal operating or routine procedures follow a tiered strategy. Engineering controls are the preferred means of long-term or permanent exposure control. If engineering controls are not feasible, appropriate use of personal protective equipment (PPE) may be considered as alternative control measures. Exposure controls for non-routine operations must be evaluated and addressed as part of the site-specific risk assessment. MSDS NAME: Ectiban Pour-On Insecticide MSDS NUMBER: SP000936 RECOMMENDED PERSONAL PROTECTIVE EQUIPMENT (PPE):
Respiratory protective equipment (RPE) may be required for certain laboratory and large-scalemanufacturing tasks if potential airborne breathing zone concentrations of substances exceed the relevantexposure limit(s). Workplace risk assessment should be completed before specifying and implementingRPE usage. Potential exposure points and pathways, task duration and frequency, potential employeecontact with the substance, and the ability of the substance to be rendered airborne during specific tasksshould be evaluated. Initial and ongoing strategies of quantitative exposure measurement should beobtained as required by the workplace risk assessment. All RPE must conform to local and regionalspecifications for efficacy and performance. Consult your site or corporate health and safety professionalfor additional guidance.
Gloves that provide an appropriate barrier to the skin are recommended if there is potential for contact withthis material. Consult your site safety staff for guidance.
Safety glasses with side shields. Use of goggles or full face protection may be required based on hazard,potential for contact, or level of exposure. Consult your site safety staff for guidance.
In small-scale or laboratory operations, lab coats or equivalent protection is required. Disposable Tyvek orother dust impermeable suit should be considered based on procedure or level of exposure. Use ofadditional PPE such as shoe coverings, gauntlets, hood, or head covering may be necessary. Consultyour site safety staff for guidance.
In large-scale or manufacturing operations, disposable Tyvek or other dust impermeable suit isrecommended and based on level of exposure. Use of additional PPE such as shoe coverings, gauntlets,hood, or head covering may be necessary. Consult your site safety staff for guidance. EXPOSURE LIMIT VALUES
No exposure limits are available for the active ingredient(s) or any other hazardous ingredient in this formulation. SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES VAPOR PRESSURE: SPECIFIC GRAVITY: SOLUBILITY:
Kerosene, diesel fuel, and xylene: Soluble
See Section 5 for flammability/explosivity information. SECTION 10. STABILITY AND REACTIVITY STABILITY/ REACTIVITY: Stable under normal conditions. INCOMPATIBLE MATERIALS / CONDITIONS TO AVOID: Oxidizers. Open flames and high temperatures. HAZARDOUS DECOMPOSITION PRODUCTS / REACTIONS: Carbon oxides (COx). Organic vapors. Chlorine. Hydrogen chloride (HCl). SECTION 11. TOXICOLOGICAL INFORMATION
The toxicological properties of the mixture(s) have not been fully characterized in humans or animals. The information presented below pertains to theformulated product unless indicated otherwise. ACUTE TOXICITY DATA MSDS NAME: Ectiban Pour-On Insecticide MSDS NUMBER: SP000936 PRODUCT / CHEMICAL NAME EXPOSURE ROUTE STUDY DESCRIPTION INHALATION: Permethrin: LC50 (4hr): 2.3 mg/L (rat) REPEAT DOSE TOXICITY DATA SUBCHRONIC / CHRONIC TOXICITY: In sub-chronic studies ranging from 14 days to 26 weeks, rats and mice were treated with oral dosages of permethrin up to 10,000 mg/kg. Dose- dependent effects such as an increase in liver/body weight ratio, hypertrophy of the liver, and clinical signs of poisoning such as tremor were observed. The no-observed effects-level (NOEL) in rats ranged from 20 mg/kg diet (in studies lasting 90 days or 6 months) to 1500 mg/kg diet (in a 6-month study). Chronic studies ranging from 1 to 2 years were conducted in rats, mice and dogs. Dosages varied with species ranging from 1 mg/kg/day to 375 mg/kg/day of permethrin. Target organs of toxicity were the liver (increased liver weight and hepatocellular swelling), lung (increased weight), and testes (decreased weight). Depression and increased mortality were observed in mice at 75 mg/kg/day and above. Additional signs and symptoms of toxicity in the rat include hyperexcitation, sparring behavior, aggressiveness, enhanced startle response, whole body tremor and prostration. REPRODUCTIVE / DEVELOPMENTAL TOXICITY: In a three-generation reproductive study with permethrin, rats were administered doses ranging from 25 to 125 mg/kg/day. Systemic effects observed in the offspring were seen in the liver (hepatocyte hypertrophy and eosinophilia) and eye (infantile glaucoma). Body tremors were observed in the parents and offspring at 125 mg/kg/day. No teratogenic effects, maternal toxicity or fetotoxicity were observed in rats and rabbits administered 200 and 400 mg/kg/day, respectively, of permethrin. MUTAGENICITY / GENOTOXICITY: Permethrin was negative in a bacterial mutagenicity study (Ames) and in a mammalian mutagenicity study (mouse lymphoma). CARCINOGENICITY: This material or product has not been evaluated for carcinogenicity.
Six carcinogenicity assays, three each in mice and rats, were conducted with permethrin. No tumorigenicity was seen in rat studies. However, speciesspecific increases in pulmonary adenomas, a common benign tumor of mice with a high spontaneous background incidence, were seen in the threemouse studies. In one of these studies, there was an increased incidence of pulmonary alveolar cell carcinomas and benign liver adenomas whenpermethrin was administered in the diet at 5,000 ppm. SECTION 12. ECOLOGICAL INFORMATION
There are no data for the final product or its formulation(s). The information presented below pertains to the following ingredient(s). ECOTOXICITY DATA INGREDIENT ECOTOXICITY
Permethrin:96-hr LC50 (rainbow trout): 0.1 to 314 ug/LPermethrin: 96-hr LC50 (brook trout): 2.3 to 5.2 ug/LPermethrin: 96-hr LC50 (channel catfish): 1.1 ug/LPermethrin: 48-hr EC50 (daphnid): 0.2 to 22 ug/L
ENVIRONMENTAL DATA OTHER INGREDIENT ENVIRONMENTAL DATA:
Permethrin is readily biodegradable. ADDITIONAL ECOTOXICITY / ENVIRONMENTAL INFORMATION: This pesticide is extremely toxic to fish and aquatic organisms. SECTION 13. DISPOSAL CONSIDERATIONS MATERIAL WASTE: Disposal must be in accordance with applicable federal, state/provincial, and/or local regulations. Incineration is the preferred method of disposal, when appropriate. Operations that involve the crushing or shredding of waste materials or returned goods must be handled to meet the recommended exposure limit(s). PACKAGING AND CONTAINERS: Disposal must be in accordance with applicable federal, state/provincial, and/or local regulations. MSDS NAME: Ectiban Pour-On Insecticide MSDS NUMBER: SP000936 SPECIAL ENVIRONMENTAL HANDLING PROCEDURES: Do not allow product to reach ground water, water courses, sewage or drainage systems. SECTION 14. TRANSPORT INFORMATION
This material is not subject to the transportation regulations of DOT, IATA, IMO, and the ADR. SECTION 15. REGULATORY INFORMATION WHMIS CLASSIFICATIONS:
The final packaged product is not subject to WHMIS classification. The following classification applies to the bulk formulation handled in the workplace.
This product has been classified in accordance with the hazard criteria on the Controlled Products Regulations and the MSDS contains all theinformation required by the Controlled Products Regulations.
B3: Combustible LiquidD1B: ToxicD2B: Toxic
TSCA LISTING INGREDIENT
Distillates, petroleum, solvent-refined light paraffinic
Distillates, petroleum, solvent-refined heavy paraffinic
Substances not included in the table above are TSCA exempt or not regulated under TSCA. SECTION 16. OTHER INFORMATION
Although reasonable care has been taken in the preparation of this document, we extend no warranties and make no representations as to the accuracyor completeness of the information contained therein, and assume no responsibility regarding the suitability of this information for the user's intendedpurposes or for the consequence of its use. Each individual should make a determination as to the suitability of the information for their particularpurpose(s). DEPARTMENT ISSUING MSDS:
Global Safety & the EnvironmentMerck & Co., Inc. One Merck DriveWhitehouse Station, NJ 08889
MERCK MSDS HELPLINE:
(800) 770-8878 (US and Canada)(908) 473-3371 (Worldwide)Monday to Friday, 9am to 5pm (US Eastern Time)
MSDS CREATION DATE: SUPERSEDES DATE: SECTIONS CHANGED (CAN SUBFORMAT): SIGNIFICANT CHANGES (CAN SUBFORMAT): MSDS NAME: Ectiban Pour-On Insecticide MSDS NUMBER: SP000936
review article Delirium in the Elderly: a review Suzanne Wass,1 Penelope J. Webster,2 Balakrishnan R. Nair3Delirium is a common disorder, often under diagnosed and mismanaged. It is becoming more prevalent, because of the ageing Accepted: 25 May 2008From the Department of 1Geriatic Medicine, Calvary Mater Hospital, NSW population. In this clinical review, we summarise the definition,